Sentences with phrase «hypertriglyceridemia in»

In conclusion, our genetic studies establish the fact that ApoC - III ASO reduces hypertriglyceridemia in mice by reducing plasma ApoC - III levels, which in turn enhances clearance of TRLs through LDLR family members.

Hyperinsulinemia in fructose - induced hypertriglyceridemia in the rat.

Not exact matches

Vascepa has been approved for use by the United States Food and Drug Administration (FDA) as an adjunct to diet to reduce triglyceride levels in adult patients with severe (≥ 500 mg / dL) hypertriglyceridemia.

The effect of Vascepa on the risk for pancreatitis and cardiovascular mortality and morbidity in patients with severe hypertriglyceridemia has not been determined.

Last December, the same research team demonstrated blocking the expression of the gene that encodes apoC - III led to major relief of triglyceridemia in patients suffering a rare and extreme form of hypertriglyceridemia, which in turn opened the door for the identification of unexpected mechanisms that govern blood fat.

By blocking the expression of a certain gene in patients, University of Montreal researchers have contributed to the demonstration of great decreases in the concentration of triglycerides in their blood, even in various severe forms of hypertriglyceridemia and regardless of the base values or the treatment the patient usually receives.

Hypertriglyceridemia, a condition in which fasting triglyceride levels are greater than 150 mg / dL, is estimated to affect at least tens of millions of American adults.

UCLA researchers have discovered a subset of people with hypertriglyceridemia whose bodies produce autoantibodies — immune - response molecules that attack their own proteins — causing high levels of triglycerides in the blood.

Added Young: «GPIHBP1 autoantibodies need to be considered in any new case of severe hypertriglyceridemia.»

This newly discovered syndrome, dubbed the «GPIHBP1 autoantibody syndrome,» represents an important advance in understanding hypertriglyceridemia, said Dr. Stephen Young, UCLA cardiologist and molecular biologist, who led the study along with his colleagues Anne Beigneux and Loren Fong.

In their new research, Young, Beigneux, Fong and Katsuyuki Nakajima, a professor at Gunma University in Japan, found a group of people with hypertriglyceridemia whose GPIHBP1 can't transport lipoprotein lipase into capillarieIn their new research, Young, Beigneux, Fong and Katsuyuki Nakajima, a professor at Gunma University in Japan, found a group of people with hypertriglyceridemia whose GPIHBP1 can't transport lipoprotein lipase into capillariein Japan, found a group of people with hypertriglyceridemia whose GPIHBP1 can't transport lipoprotein lipase into capillaries.

TNF - α and IL - 6 also increase lipolysis and have been implicated in the hypertriglyceridemia and increased serum FFA levels associated with obesity (31, 32).

General Product Information Obesity - High Fat Diets for Diet - Induced Obesity Models Metabolic Syndrome - Diet - Induced Metabolic Syndrome in Rodent Models Diabetes - High Fructose / Sucrose Diets for inducing Hypertriglyceridemia and Insulin Resistance in Rodents Atherosclerosis - Diet - Induced Atherosclerosis / Hypercholesterolemia in Rodent Models Hypertension - Phenotypic Expression of Hypertension in Rodent Models through Dietary Manipulation NAFLD (Non-alcoholic Fatty Liver Disease) Cancer - Creating a Clean Background for Oncology Research Test Compounds / Kaolin Pellets Diet and Immunology Focus: Arsenic in Grain - Based Laboratory Animal Diets and Effects on the Rodent Toxicological Phenotype Focus: The Importance of a Proper Control Diet

Sucrose is made up of glucose and fructose and it has been shown that diets very high in sucrose or fructose (~ 60 - 70 % by energy) can induce hypertriglyceridemia, insulin resistance and fatty liver.

LPL is a pivotal player in TG metabolism, as mutations in LPL or in its cofactors (ApoC - II, glycosylphosphatidylinositol - anchored high - density lipoprotein — binding protein 1, lipase maturation factor 1) account for the majority of monogenic hypertriglyceridemia cases (25).

Transgenic overexpression of APOC3 in mice also led to hypertriglyceridemia that was likely due to defective lipolysis (20), but it should be noted that an excess of any apolipoprotein has a similar effect (26 — 29), probably by shielding the core TG and preventing LPL access.

These ratios of ApoC - III to ApoC - II exceed the normal physiological range of these apolipoproteins present on human VLDL particles, even in patients with hypertriglyceridemia (0.7 to 2)(30).

Our results support a model in which ApoC - III on TRLs contributes to hypertriglyceridemia, primarily by preventing TRL hepatic clearance via both LDLR and LRP1.

However, far from encouraging people to consume unhealthy fats, this promising outcome may result in new therapeutic uses of Incas» peanut for the treatment of both hypertriglyceridemia and type 2 diabetes, as well as in new ways of preventing cardiovascular and metabolic diseases.

The addition of sacha inchi oil slowed down glucose production in 16 (38.1 %) participants that showed a higher concentration of triglycerides before meals (fasting hypertriglyceridemia), whereas an improved expression of sirtuin - 1 (SIRT1), a gene responsible for regulating energy within the cells and coordinating cellular functions, was registered four hours after ingesting the meal enriched with sacha inchi oil, and linked to lowered levels of blood sugar measured at the same time.

Hypertriglyceridemia, defined as a fasting plasma Triglyceride (TG) concentration of more than 150 mg / dL, is a common condition in the United States.

~ Effect of high - amylose starch and oat bran on metabolic variables and bowel function in subjects with hypertriglyceridemia (human study — full text) «We compared the effects of a diet in which 25 % of the carbohydrate was replaced by high - amylose starch with those of a similar diet high in oat bran or low - amylose starch in 23 hypertriglyceridemic subjects who were overweight mostly because of abdominal adiposity.

An extreme example of TOFI is lipodystrophy were people can not gain body fat and quickly develop diabetes, hyperinsulinemia, fatty liver, hypertriglyceridemia and heart disease because they aren't able to buffer their energy in their fat stores before it goes to their vital organs.

After an initial level of care is provided, your veterinarian will address problems such as blood sugar (hyperglycemia) and too much fat (triglycerides) in the blood (called hypertriglyceridemia).

Additional causes include: atherosclerosis (cholesterol plaques like humans get) associated with hypothyroidism, hypertriglyceridemia (elevated blood fat levels) in miniature schnauzers, and cancer.

Hypertriglyceridemia was proposed as a possible inciting cause of canine pancreatitis (105) and is commonly seen in diabetic dogs (81).