We also found that a protein involved in modulating the sleep - wake cycle called orexin /
hypocretin also influences Aβ levels in the brain.
Not exact matches
Here about 750 cells produce orexin (
also known as
hypocretin), a hormone that promotes wakefulness.
Think of brain cells as rooms with locks called receptors on their surfaces and a
hypocretin as a key that is
also a stimulant.
Relying on tests that used blood from Pandemrix recipients, the study authors showed it triggered antibodies that not only attack the virus but
also bind to
hypocretin receptors, potentially killing them.
Spinal fluid from living narcoleptics
also has revealed an almost complete absence of
hypocretin.
In line with the «molecular mimicry» idea, he
also thought he had identified viral proteins that resembled
hypocretin.
Orexins are
also known as
hypocretins.
Hypocretin neurons, about which I have
also written before, up - regulate wakefulness and the stress response.
Because 1)
Hypocretins simultaneously stimulate appetite and wakefulness, particularly through orexigenic output of the melanocortin system, and subsequent release of CRH, which activates the stress response, and 2) while
Hypocretin Neurons wake us up, they
also need to be quiet enough for people to go to sleep.
I have
also personally experienced metabolic distress as a result of fasting, which is evidenced by my interest in
hypocretin neurons.
Ghrelin, which originates in the gut and is known to stimulate appetite,
also excites
Hypocretin Neurons.
GABA neurons
also create a bridge between Neuropeptite Y, which is the molecule that arguably has the strongest appetite - stimulating effect on the brain, and
Hypocretin Neurons (more on Neuropeptide Y later this week).
This is coupled by ghrelin activity, which is
also detected by
Hypocretin Neurons.
Norepinephrine and orexin (
also called
hypocretin) keep some parts of the brain active while we are awake.