Sentences with phrase «hypomethylation in»

Inadequate dietary intake of methyl groups leads to hypomethylation in many important pathways, including 1) disturbed hepatic protein (methionine) metabolism as determined by elevated plasma homocysteine concentrations and decreased S - adenosylmethionine concentrations, and 2) inadequate hepatic fat metabolism, which leads to steatosis (fatty accumulation) and subsequent plasma dyslipidemia.

However, he did not mention that we also know that hypomethylation in DNA synthesis, which can occur with inadequate folate intake, can also cause DNA synthesis errors and chromosome breakage, which can initiate cancer formation.

This unbiased approach revealed global hypomethylation in the cancer cell line (HCC1954) relative to epithelial cells (HMEC), and some specific patterns:

Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T. (2017) The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.

Not exact matches

Such epigenetic mechanisms have already been exploited for diagnosis and treatment; for example, DNA hypomethylation therapy with 5 - azacytidine is approved for MDS and is in clinical trials for some other cancers.

In regions of DNA hypomethylation, H3K27me3 and H3K9me3 form repressive chromatin domains.

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer Genome Research, 22 (2), 246 - 258 DOI: 10.1101 / gr.125872.111

The authors looked at gene expression in a panel of 50 ERBB2 (Her2) positive breast tumors and found that this pattern held up: DNA hypomethylation is associated with decreased gene expression in breast cancer.

Non-CpG island promoter hypomethylation and miR - 149 regulate the expression of SRPX2 in colorectal cancer.

12:30 PM Defects of the maintenance methyltransferase DNMT1 lead to progressive neurological phenotypes in association with global hypomethylation.