Sentences with phrase «hypomethylation with»
Not exact matches
Such epigenetic mechanisms have already been exploited for diagnosis and treatment; for example, DNA hypomethylation therapy with 5 - azacytidine is approved for MDS and is in clinical trials for some other cancers.
http://massgenomics.org/
Finally, we show that hypomethylation is associated with reduced levels of the de novo DNA methyltransferases Dnmt3a and Dnmt3b and that ectopic expression of these factors restores global methylation levels.
The authors looked at gene expression in a panel of 50 ERBB2 (Her2) positive breast tumors and found that this pattern held up: DNA hypomethylation is associated with decreased gene expression in breast cancer.
12:30 PM Defects of the maintenance methyltransferase DNMT1 lead to progressive neurological phenotypes in association with global hypomethylation.
However, he did not mention that we also know that hypomethylation in DNA synthesis, which can occur with inadequate folate intake, can also cause DNA synthesis errors and chromosome breakage, which can initiate cancer formation.