Sentences with word «hypomorphic»

The study was performed using several founder lines, bred onto a background strain of mice hypomorphic for BubR1 (BubR1H / H), a key component of the mitotic checkpoint machinery.

We describe a heteroallelic, hypomorphic genotype of mutantInR, which yields dwarf females with up to an 85 % extension of adult longevity and dwarf males with reduced late age - specific mortality.

The corresponding hypomorphic, mutant allele was thus designated as homozygous lethal († XPCS).

Although direct modification of zygotic genomes may have some advantages, the strategy can result in mosaic or hypomorphic mutation of injected animals [27]--[31], for which mutation may fail to transmit to offspring [27] and breeding will need to be further performed for obtaining homozygous (nonmosaic) animals [29].

Gene × environment effects: stress and memory dysfunctions caused by stress and gonadal factor irregularities during puberty in control and TGF - alpha hypomorphic mice

4:30 pm - 5:30 pm Gerard P. Zambetti, PhD St. Jude Children's Research Hospital The hypomorphic Brazilian mutant TP53 - R337H and variable tumor susceptibility: identification of a potential genetic modifier

The Pkd1 (V / V) mice show a hypomorphic phenotype, characterized by a delayed onset and distal nephron segment involvement of cystogenesis at postnatal maturation stage.