Sentences with word «hypomyelination»

Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor cells isolated from the developing or adult CNS, or from human embryonic stem cells, it has been possible to generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].

There is no actual treatment for hypomyelination.

Although genetic deletion of BACE1 results in abolished amyloid pathology in AD model mice, it also results in neurodevelopmental phenotypes such as hypomyelination and synaptic loss, observed in schizophrenia and autism - like phenotype.

When this protective sheath is too thin, as in hypomyelination, the electrical impulses can get lost between nerves and cause the nerves and corresponding muscles to malfunction.

Male Springer Spaniel puppies suffer most from hypomyelination because the form of genetic transmission is different in this breed.

Congenital hypomyelination is seen as a familial / inherited disorder in Springer Spaniels, Chow Chows, Weimaraners, and Bernese Mountain Dogs, usually with signs developing around 2 — 8 wk of age.

Golden Retrievers inherit a form of shaking puppy syndrome that involves the peripheral nervous system, rather than the central nervous system, causing them to develop all other symptoms of hypomyelination minus the shaking.

Tests may be run to detect the genetic mutation responsible for hypomyelination, though some dogs can be asymptomatic carriers of the genetic defect.

So do several blood - clotting diseases (von Willebrand's disease, hemophilia A, and factor XI deficiency), a neurological disease (hypomyelination) that causes tremors in puppies, and a disease (hyperuricosuria) that predisposes a Weimaraner to forming urinary stones.

Topics addressed include testing for hyperuricosuria (HUU) and hypomyelination (shakey puppy).

Shaking puppy syndrome, or hypomyelination, affects a young dog's central or peripheral nervous system and involves the entire body.

Hypomyelination is hereditary, and certain breeds are predisposed to developing the condition.

Diagnosis of hypomyelination is generally by ruling out all other potential problems.

Two types of hypomyelination have been described to date, Shaking Pup Syndrome in the English Springer Spaniel, and a second type found primarily in the Weimaraner, but also reported in a single study as being found in Chow Chows.

Use of trichlorfon during pregnancy can cause a congenital tremor in piglets due to both cerebellar hypoplasia and hypomyelination.

Hypomyelination is a disease of the central nervous system.