Because the hypothalamus is a major control center of the endocrine system, appetite and energy balance, Kahn and his team wanted to know how diabetes affects
hypothalamic gene expression.
These featured similar anorexigenic effects of intranasal insulin with decrease in meal frequency and total food intake together with comparable changes in
hypothalamic gene expression (262, 264).
In males, paraventricular
hypothalamic gene expression was down - regulated, potentially indicating an important adaptation to maintain glucose homeostasis in male offspring (148).
Not exact matches
Moderate level fetal alcohol exposure and serotonin transporter
gene promoter polymorphism affect neonatal temperament and limbic -
hypothalamic - pituitary - adrenal axis regulation in monkeys.
The study identified five
genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1);
hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a
gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).
«The Y6
gene is highly expressed in a part of the brain called the «
hypothalamic suprachiasmatic nucleus», which is known to control the body's circadian rhythm and may also critically modulate metabolic processes in response to food.
Mariman EC, Bouwman FG, Aller EE, van Baak MA, Wang P. Extreme obesity is associated with variation in
genes related to the circadian rhythm of food intake and
hypothalamic signaling.
Moderate level fetal alcohol exposure and serotonin transporter
gene promoter polymorphism affect neonatal temperament and limbic -
hypothalamic - pituitary - adrenal axis regulation in monkeys.