The cellular mechanisms underlying this bursting behavior have been studied in vitro, using either acute slices of the adult hypothalamus, or organotypic cultures of neonatal
hypothalamic tissue.
The tumor - derived peptide is identical in biological activity and similar in physiochemical properties to the still uncharacterized growth hormone - releasing factor present in extracts of
hypothalamic tissues.
To further probe NF - κB's effects on aging, the researchers then either inhibited or constitutively activated the protein in mouse
hypothalamic tissues by manipulating the upstream activator IKK - β.
Not exact matches
This is associated with modification of
hypothalamic nitric oxide release that favors glucose uptake in metabolic
tissues such as skeletal muscle, liver, and adipose
tissue.
Chrousos, G.P., The role of stress and the
hypothalamic - pituitary - adrenal axis in the pathogenesis of the metabolic syndrome: neuro - endocrine and target
tissue - related causes.