Sentences with phrase «hypoxia on»

He also spent a year of research at the University of California, San Diego Medical School investigating the effects of hypoxia on gene expression and regulation in the brainstems of mice.

This would bypass the potential adverse effects of hypoxia on the CSC fraction while limiting tumor progression due to the general vasculature effects.

We studied the effects of hypoxia on CSC activity, using in vitro mammosphere and holoclone assays as well as in vivo limiting dilution experiments, in 13 patient - derived samples and four cell lines.

To mechanistically explain the effect of hypoxia on CSC, we assessed the roles of ER - α and Notch signaling.

The aims of this study, therefore, were to assess the effects of hypoxia on breast CSC in cell lines and primary samples and to elucidate the mechanism by which these changes take place.

Although extensive efforts have been devoted to understanding the effect of hypoxia on tumor progression, two areas of tumor biology remain unclear.

Little is known about the molecular effects of hypoxia on the retina and the underlying relationship between hypoxia and the pathogenesis of retinal diseases.

The effects of chronic prenatal hypoxia on the fetal and adult offspring cardiovascular system are prevented by maternal treatment with vitamin C during pregnancy.

Effects of bottom - water hypoxia on sediment bacterial community composition in a seasonally hypoxic enclosed bay (Omura Bay, West Kyushu, Japan)-- FEMS Microbiology Ecology

«Despite recent alarm about inner - shelf hypoxia on the Oregon coast, there appears to be no hypoxia currently in the main channel of Coos Bay, and there is little evidence of past hypoxia in the estuary,» Sutherland and co-author Molly A. O'Neill wrote in their conclusion.

Not exact matches

If the initial work rate and RPE are set in a feedforward or anticipatory manner as is suggested (B and C on fig 2), then the starting power output should be similar whenever exercise is performed at a given RPE, irrespective of experimental interventions, such as increased ambient temperatures, hypoxia and dietary interventions.

The cold can have extremely negative, and even destructive impact on a fetus, lead to his hypoxia or cause the miscarriage at all.

The prone or side sleep position can increase the risk of rebreathing expired gases, resulting in hypercapnia and hypoxia.54, — , 57 The prone position also increases the risk of overheating by decreasing the rate of heat loss and increasing body temperature compared with infants sleeping supine.58, 59 Recent evidence suggests that prone sleeping alters the autonomic control of the infant cardiovascular system during sleep, particularly at 2 to 3 months of age, 60 and can result in decreased cerebral oxygenation.61 The prone position places infants at high risk of SIDS (odds ratio [OR]: 2.3 — 13.1).62, — , 66 However, recent studies have demonstrated that the SIDS risks associated with side and prone position are similar in magnitude (OR: 2.0 and 2.6, respectively) 63 and that the population - attributable risk reported for side sleep position is higher than that for prone position.65, 67 Furthermore, the risk of SIDS is exceptionally high for infants who are placed on their side and found on their stomach (OR: 8.7).63 The side sleep position is inherently unstable, and the probability of an infant rolling to the prone position from the side sleep position is significantly greater than rolling prone from the back.65, 68 Infants who are unaccustomed to the prone position and are placed prone for sleep are also at greater risk than those usually placed prone (adjusted OR: 8.7 — 45.4).63, 69,70 Therefore, it is critically important that every caregiver use the supine sleep position for every sleep period.

Senator Charles Schumer, the Senate minority leader, has called on Congress to quickly pass the Harmful Algal Bloom and Hypoxia Research and Control Act, which he said would help combat the rise in toxic algae found in Long Island waterways.

It was a gene called the von Hippel - Lindau (VHL) factor, which encodes a protein that puts a brake on the cellular hypoxia response.

This suggests that the effects of hypoxia could be more significant during whole body exercise, in which the stress on the cardiovascular system is more pronounced.

Plan to shrink Gulf dead zone Environmental Protection Agency background on dead zones Hypoxia in the Gulf of Mexico

Key aspects of ischemia - reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2 - ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2 - sensing HIF (hypoxia - inducible factor) hydroxylase EGL - 9.

They argue that fetal monitoring trials have focused on uncommon outcomes, such as cerebral palsy, which is rarely linked to hypoxia during labour, and say «we should be focusing on other forms of evidence relating to the more common outcome with serious long term implications — namely, neonatal encephalopathy.»

He points out that babies still die or are damaged because of intrapartum hypoxia and that focusing entirely on the fetal heart rate without taking account of other relevant risk factors «may create a lack of situational awareness and lead to adverse outcomes.»

Recent studies showed that low oxygen conditions increase levels of a family of proteins known as HIFs, or hypoxia - inducible factors, that turn on hundreds of genes, including one called NANOG that instructs cells to become stem cells.

Published in Nature Medicine on May 1, 2017, the study demonstrates chronic ischemic hypoxia (lack of blood and oxygen) after spinal cord injury and how blood flow plays a key role in the cause and treatment of motor disorders.

For example, the authors note that sleeping on the stomach and exposure to tobacco smoke can also contribute to hypoxia — insufficient oxygen reaching the tissues.

The Gulf task force, in its 2008 report, states that «hypoxia has negative impacts on marine resources.»

As the severity of Lake Erie harmful algal blooms has been on the rise, some would look for a link between summertime algal blooms and hypoxia.

Gibbons adds that millions of years of adaptation to low - oxygen waters allowed the goby «to capitalize on the changes to the system — both increased hypoxia and [hydrogen sulfide] as well as the jellyfish.»

The team of clinical neuropsychologists at Saarland University have used this training programme on eleven stroke patients, nine patients with brain trauma injury and four hypoxia patients.

The research, led by the University of Southampton and UCL, which took place on Mount Everest, assessed the mechanisms by which low oxygen levels in the body — known as hypoxia — are associated with the development of insulin resistance.

The hypoxia forecast is based on models developed by NOAA - sponsored researchers at the University of Michigan and the University of Maryland's Center for Environmental Science.

«Understanding the sources and transport of nutrients is key to developing effective nutrient management strategies needed to reduce the size of hypoxia zones in the Gulf, Bay and other U.S. waters where hypoxia is an on - going problem.»

By testing the sensor on volunteers during a simulation in which oxygen levels were cut, the team was able to identify a set of VOCs signalling the onset of hypoxia.

«This work on Gulf hypoxia is a great example of interagency teamwork between NOAA and USGS to work across the land - sea boundary.»

The implications of these data are that maternal treatment with antioxidants may provide possible therapy against the programming effects on vascular dysfunction in pregnancy complicated by fetal hypoxia, such as during placental insufficiency, preeclampsia, gestational diabetes or high altitude pregnancy.

Thus, interactome hubs such as NR1 may exhibit low levels of change in individual gene expression following hypoxia, but, based on analysis of interaction networks, are likely to play an important role in regulating the biologic response.

Deeper insights into its hypoxia problems could help restoration efforts on this economically important lake and others like it.

Northern blotting analyses were performed on control and 3 h hypoxic samples to confirm that mRNA levels for P0 remained unchanged during hypoxia.

Our results focused on mRNA expression and not protein expression or functional NMDAR changes after hypoxia and recovery.

Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring.

New models of perinatal hypoxia were developed in rats with emphasis on the potential protective effect of pre-conditioning by a previous fetal hypoxic period.

Furthermore, studies are performed on fetal cardiovascular adaptation to hypoxia and its short and long term consequences.

A recent theme of his research is on the consequences of hypoxia - ischemia and inflammation.

The percentage of CSCs in the cycling hypoxia selected subpopulation was analyzed based on the CD44, CD24, ESA, and E-cadherin expression by three - color flow cytometry.

Based on his team's earlier work, Mootha wasn't surprised that the mice treated with hypoxia lived longer.

To study the effect of hypoxia / reoxygenation cycles on breast cancer, we exposed two metastatic human breast cancer cell lines (MDA - MB 231 and BCM2) to cycles of chronic hypoxia and nutrient deprivation.

It has been postulated that hypoxia contributes directly to the development of more aggressive cancers by exerting selective pressure on the tumor cell population to favor cells that can survive decreased O2 and nutrients [18 — 20].

The most common animal model used to study OSA today is intermittent hypoxia (IH) which relies solely on exposing animals to a decrease in blood oxygen levels.

He did a post-doc in the lab of Professor Chris Schofield working on the Hypoxia - inducible - factor hydroxylase Factor - Inhibiting - HIF and enzymes involved in biosynthesis of clavulanic acid.

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

To mimic the in vitro hypoxic response in vivo, we developed a xenograft model based on the hypothesis that with increasing xenograft sizes, there will be a parallel increase in hypoxia due to rapid cell proliferation and restricted blood supply to the xenograft cells.

Culture for 48 hours in hypoxia had no significant effect on proliferation or apoptosis (Supplementary Fig.