Sentences with phrase «hypoxic cancer»

(a) The oxidative catabolism of free fatty acids and amino acids (via the Respiratory Chain and Citric Acid Cycle) might be inhibited in hypoxic cancer cells via the judicious use of agents which inhibit their availability, i.e., partially inhibit hepatic fatty acid synthesis and keep plasma amino acid levels within the normal range, thus decreasing ATP production;

In normoxic cells, the transcription factor HIF - 1α is degraded by the action of E3 ubiquitin ligase on the oxygen - dependent degradation domain (ODD) of HIF - 1α; however HIF - 1α is stabilized and therefore, accumulates in hypoxic cancer cells.

Cadherin - 22 is located on cell surfaces, allowing hypoxic cancer cells to stick together and migrate collectively as a group, said Uniacke.

Not exact matches

Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this protein in cancer therapy, we engineered a human cell line with an additional genetic circuit that produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.

In the mice with cancer, the probes enabled detailed, 3 - D ultrasound imaging of hypoxic tumors.

During tumor development, rapid expansion of cancer cells creates a hypoxic microenvironment that is followed by periods of reoxygenation to promote tumor progression.

Our findings suggest that this is also true in breast cancer as EGFR inhibition blocked the hypoxic CSC effect in ER - α — positive tumors.

Future studies need to clarify whether smaller subgroups of breast cancer, defined according to expression array criteria, will behave in ways similar to ER - α — positive or negative breast cancer but it is clear that the 2 major disease subgroups, defined by ER - α status, show contrasting hypoxic CSC responses.

In summary, our novel data suggest that ER - α — positive and negative breast cancer subtypes respond differently to hypoxic exposure and as a consequence, anti-HIF-1α or antiangiogenic therapies will not be suitable for both subtypes.

Recent reports show increased CSC activity following hypoxic exposure in breast cancer cell lines (18 — 20), but no reports have studied this rare population in primary human breast cancer samples.

Hypoxic effect requires Notch signaling in ER - α — positive cancers.

Figure 6A and B show putative models of the hypoxic effects in breast cancer.

Putative model of breast cancer cell hierarchy and the hypoxic effect.

As distinct hypoxic responses were observed between ER - α — positive and negative breast cancers, we hypothesized that the response seen in ER - α — positive cancers was downstream of ER - α.

Importantly, NSCs can target breast cancer metastasis in the brain [9] and can penetrate deep and hypoxic regions of solid tumors [7].

Dormant tumor cells in a hypoxic bone marrow niche (19) will be enriched for CSC in ER - α — positive breast cancer but depleted in ER - α — negative cancers profoundly influencing the capacity for late disease recurrence.

As the mechanistic studies suggest that ER - α and Notch are central in mediating the unfavourable hypoxic CSC response in ER - α — positive breast cancer, they may offer an attractive combination treatment approach, which would consist of ER - α or Notch inhibitors combined with antiangiogenic drugs.

There was a HIF - 1α — dependent CSC increase in ER - α — positive cancers following hypoxic exposure, which was blocked by inhibition of estrogen and Notch signaling.

Cancer stem cells (CSCs) in the hypoxic BM regions are blamed for the incurability of MM, because CSCs are often resistant to drugs currently used against BM cancers (including proteasome inhibitors and immunomodulatory agents).

In 1924, the Nobel Laureate Otto Heinrich Warburg, determined that cancer cells have a dependency on glucose for growth and metastastic processes under hypoxic (low oxygen conditions), using glycolysis

Many disease states especially cancer is in a hypoxic state and in need of oxygen for repair and healing.

Neinstein's lawyers have experience with a wide variety of malpractice suits, including those regarding nursing errors, cardiac arrest, medication errors, hypoxic brain injuries, sepsis, surgical negligence, atrial fibrillation, tPA administration, acquired brain injuries, and a number of different forms of cancer.

-- Birthing injuries — Acquired brain injuries — tPA administration — Atrial fibrillation — Surgical negligence — Cardiac arrest — Sepsis — Hypoxic brain injuries — Breast, colon, lung, and prostate cancer — Failure to monitor — Medication errors, and — Nursing errors

Each Neinstein medical malpractice lawyer has experience litigating a wide variety of malpractice cases, including surgical negligence, cancer, cardiac arrest, sepsis, hypoxic brain injuries, acquired brain injuries, tPA administration, atrial fibrillation, medication or nursing errors, and birthing injuries.