Sentences with phrase «hypoxic conditions»

"Hypoxic conditions" refers to a situation where there is not enough oxygen available. Full definition
Interestingly, Rho kinase inhibition under hypoxic conditions produced a more effective increase in chondrocyte - specific gene expression and synthesis of extracellular matrix components by HCS - 2 / 8 cells.
However, the offspring of these adults, when reared in hypoxic conditions showed less ability to regulate their oxygen uptake and were significantly smaller than those of normoxic parents, potentially because they were having to expend more energy simply to survive in those conditions.
Higher CH4 emission is likely explained by a higher supply of organic matter under more hypoxic conditions, where CH4 oxidation is less likely to occur.
These «aggregates» can comprise hundreds of thousands of cells, be up to 2 mm in diameter and be eight times more resistant to chemotherapy drugs — firstly because hypoxic conditions are created inside the aggregates and secondly because these tumour cells reduce growth and are therefore less sensitive.
Over time in continued hypoxic conditions, these vessels become muscularized, resulting in pulmonary hypertension, high blood pressure in the blood vessels of the lung.
Combined with the wind, seawater remains longer in the shallower estuaries as the summers get dry, making for stagnant conditions, less flushing and more lethal hypoxic conditions.
«Oregon's Coos Bay historically has avoided serious hypoxic conditions: Narrow offshore shelf, a dredged ship channel and fresh river water combine to keep the bay flushed, but that could change as the climate warms.»
But a different result was unexpected: A switch to hypoxic conditions seemed to actually reverse existing brain damage.
Melanocytes have the capacity to respond to a diverse number of extracellular signals, including UVR, endocrine signaling cascades that occur during pregnancy, micro-environments of the stem cell hair bulge vs. differentiated hair follicle niches, and hypoxic conditions found in metastatic melanoma tumors.
A study by the University of Plymouth showed that exposure to even moderate hypoxia can have markedly different effects on metabolic performance, depending on whether adults are exposed to short - term hypoxia or undergo the whole of their development under hypoxic conditions.
The researchers first confirmed that the switches are only triggered in hypoxic conditions.
And it is under these hypoxic conditions that the new switch becomes activated.
«Our results are consistent with the oxygen levels shown to influence blue crab behaviors in both field and laboratory settings,» says Brill, and «support the idea that blue crabs are well adapted to the hypoxic conditions occurring in the estuarine environments they occupy.»
Their findings indicate that this pest species is better adapted to hypoxic conditions.
Dr Truebano added: «The observation that these small and seemingly insignificant estuarine animals, reared in hypoxic conditions, become physiologically compromised as adults is a cause of concern for this species.
Are they innate or do they require the fish to learn or be exposed to hypoxic conditions to develop appropriate adaptations?»
Mount Everest presents endless challenges to the adventurer who dares to seek its summit: treacherous overpasses, tumbling house - sized blocks of ice and hypoxic conditions, to name a few.
Under the hypoxic conditions, the body might produce more reactive oxygen species (ROS), harmful compounds that can damage DNA.
Hypoxic conditions were used to model the oxygen tension present in healthy cartilage tissue.
The female cells also seem better equipped to deal with the hypoxic conditions and reactive oxygen species found in injured and diseased muscle, as they up - regulated more stress - related and antiapoptotic genes.
In addition, temporal [17] and spatial [16,17] correlations between increased levels of HIF - 1α, the regulatory subunit of HIF - 1, and increased VEGF expression have been shown, indicating that HIF - 1 may control the expression of VEGF in the retina under hypoxic conditions.
Microarray analysis was performed at different time points to determine yeast genome - wide response when exposed to salt, acid, hypoxic conditions, and hydrogen peroxide, as well as ethanol, isopentenol, and other biofuels candidates.
After one cycle of hypoxia and reoxygenation, we observed a small cell population that survived hypoxia as spherical clusters under hypoxic conditions and that resumed proliferation after reoxygenation.
The p38 - mediated p53 phosphorylation at Ser15 and subsequent p53 induction has been reported to be responsible for apoptosis induced by nitric oxide, hypoxic conditions, DNA - damaging agents, 1 - nitropyrene, and benzo [a] pyrene [30 - 32].
GSC adaptations to hypoxic conditions.
GSCs have a high capacity for self - renewal, survival under hypoxic conditions, resistance to radiation and high invasive potential.
They found that exosomes derived from older children's cells were only reparative if they were subjected to hypoxic conditions (lack of oxygen), while exosomes from newborns» cells improved rats» cardiac function with or without hypoxia.
These results suggest that low - intensity resistance exercise in the hypoxic condition caused greater metabolic and hormonal responses than that in the normoxic condition.
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