Sentences with phrase «hypoxic exposure»

There was a HIF - 1α — dependent CSC increase in ER - α — positive cancers following hypoxic exposure, which was blocked by inhibition of estrogen and Notch signaling.

Recent reports show increased CSC activity following hypoxic exposure in breast cancer cell lines (18 — 20), but no reports have studied this rare population in primary human breast cancer samples.

In summary, our novel data suggest that ER - α — positive and negative breast cancer subtypes respond differently to hypoxic exposure and as a consequence, anti-HIF-1α or antiangiogenic therapies will not be suitable for both subtypes.

However, only few studies showed or discussed the possibility of establishing irreversible phenotypes through cycling hypoxic exposure without genetic manipulation [41, 42].

The occurrence of reoxygenation following hypoxic exposures of various degrees is inherent in the dynamic nature of the tumor vasculature [43, 44].

Not exact matches

This leads to a suggestion that in utero nicotine exposure causes brain stem anomalies that results in their hypoxic arousal mechanisms not working properly.