Shan Ping Yu and Ling Wei, who moved their laboratories about a year ago to Emoryâ $ ™ s Department of Anesthesiology, were the first to show the effects of «
hypoxic preconditioning.»
Interestingly, it has been suggested that the initial signal responsible for triggering the development of
hypoxic preconditioning in the brain involves the opening of ATP - sensitive potassium channels via the activation of adenosine A1 receptors [69].
Several studies have investigated the genomic response of the brain to
hypoxic preconditioning.
However, within the group that remain altered after 24 h are some genes that may underly the positive effects of
hypoxic preconditioning [43,63].
Key aspects of ischemia - reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2 - ON response, which is suppressed by
hypoxic preconditioning or inactivation of the O2 - sensing HIF (hypoxia - inducible factor) hydroxylase EGL - 9.