Sentences with phrase «hypoxic regions of»
Importantly, NSCs can target breast cancer metastasis in the brain [9] and can penetrate deep and hypoxic regions of solid tumors [7].
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One percent oxygen was used to represent hypoxia, although levels of oxygen will also vary within hypoxic regions of tumors.
Not exact matches
«The IMM teams showed clearly that the gene was switched on only in hypoxic regions,» says Sue Kingsman, the research director of Oxford BioMedica.
When oxygen is scarce, however, HIF - 1α starts to accumulate and turns on the expression of a host of genes that assist in promoting and increasing oxygen delivery to hypoxic regions.
Their study showed that the protein neuropilin - 1 (Nrp1) is crucial for the localization of TAMs inside hypoxic tumor regions, which strengthens the pro-tumoral characteristics of TAMs.
Furthermore, these results also have an important prognostic value — the positioning of macrophages in hypoxic tumor regions would be an indication of a poor prognosis, while the localization of macrophages in normoxic regions of the tumor could predict a better disease outcome.
They have engineered macrophages to deliver a therapeutic virus to hypoxic tumor regions, which respond poorly to conventional treatments such as chemotherapy and radiation because of an insufficient blood supply.
As the duration and extent of hypoxic areas is predicted to increase in coastal regions, it is likely that some species will be exposed chronically throughout their life cycle.
The 2015 Chesapeake Bay forecast calls for an oxygen - depleted, or hypoxic, region of 1.37 cubic miles, about 10 percent below the long - term average.
Farmland runoff containing fertilizers and livestock waste is the main source of the nitrogen and phosphorus nutrients that cause the annual Chesapeake Bay hypoxic region, which is also known as a dead zone.
The irregular vasculature of solid tumors creates hypoxic regions, which are characterized by cyclic periods of hypoxia and reoxygenation.
Cancer stem cells (CSCs) in the hypoxic BM regions are blamed for the incurability of MM, because CSCs are often resistant to drugs currently used against BM cancers (including proteasome inhibitors and immunomodulatory agents).
The hypoxic zone forms in the middle of the most important commercial and recreational fisheries in the coterminous United States and could threaten the economy of this region of the Gulf.