Sentences with phrase «hypoxic tumours»
In order to overcome these problems, Dr. Kizaka - Kondoh and his colleagues at Tokyo Institute of Technology developed a novel, highly - specific, functional imaging probe that can detect hypoxic tumours with HIF activity, which is a hallmark of malignancy and poor prognosis.
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Therefore, a protein containing the ODD would be intact in hypoxic tumours, but destroyed in normoxic tissues.
Not exact matches
These «aggregates» can comprise hundreds of thousands of cells, be up to 2 mm in diameter and be eight times more resistant to chemotherapy drugs — firstly because hypoxic conditions are created inside the aggregates and secondly because these tumour cells reduce growth and are therefore less sensitive.
«We would hope to create little protein factories in the tumour cell that are only switched on when the cells are hypoxic,» says Kingsman.
CEN - 209 has the potential to destroy the areas of tumours which are low in oxygen — or hypoxic.
Perfusion of microvessels in Tie2PEKO mice was further confirmed by similar extent of hypoxic areas as compared to tumours growth in wild - type mice (Supplementary Fig. 12b).
Hypoxic areas were normalized to the total tumour area.