Sentences with phrase «inkt cell selection»

Seven patients underwent a blood cell selection process (apheresis) to harvest a certain population of their white blood cells.

However, because IFN - γ is widely known to influence several endothelial properties, such as junctional integrity (21) and adhesion molecule expression (22), we elected to remove this cytokine from cultures immediately after the second session of cell selection.

Identify immune cell populations with our flow cytometry antibodies and kits and isolate them with our cell selection kits.

Cells grown with this culture system are maintained in an undifferentiated state with virtually no detectable background differentiation, eliminating the need for cell selection.

Immunotherapeutic strategies are rapidly evolving, and recent advancements in cell selection and gene editing have reshaped the reality of immunotherapy.

Not exact matches

Samples are weighted to correct for unequal selection probability, nonresponse, and double coverage of landline and cell users in the two sampling frames.

Perhaps you could explain how genetic selection works on the Sickle cell?

Rather, before we make hasty, uninformed guesses about things as enormously complicated as whole organs and animals, we must first look at life's foundation» molecules and cells» to see what natural selection can explain there.

They include going after the damage to cells done by free radicals, making use of hormone therapy, or caloric restrictions, or vitamin supplements, or, most dramatically, healthy gene selection through pre-implantation genetic diagnosis and even repairing the entire human genome.

It is no longer simply a matter of cells organized by the hazards of natural selection, but of completed zoological units inventively building themselves into organisms on a planetary scale.

If, on the other hand, we define evolution in the Darwinian sense — as a process of random mutation and natural selection by which all living beings have arisen by chance from single - celled organisms over 100's of millions of years — we may not be on equally firm ground from a scientific perspective.

As natural selection kicked in, these bacteria graudally evolved into eukaryotic cells, then small colonies, then multicellular organsims, then pre-Cambrian biota, then crusaceans, jellyfish and, later, fish.

The first offering from the partnership is a completely new cell phone case for iPhone: distinctive Griffin industrial design wrapped in a selection of favorite original Threadless images!!

Silk Innovation offers a diverse selection of cell phone cases that are stylish and practical.

We've talked about SMS messages in politics for years on Epolitics.com (remember when Obama offered to whisper the name of his VP selection into your cell phone in 2008?)

Samples are weighted to correct for unequal selection probability, nonresponse, and double coverage of landline and cell users in the two sampling frames.

The campaign also amassed a central list of roughly one million cell numbers and used SMS text messages to promote voter turnout as well as to make campaign announcements such as Joe Biden's selection as Vice President.

For now, drugs such as rituximab that deplete B - cells not only offer potential relief for those with autoimmune illnesses, but a new way of understanding these conditions — as an unintended consequence of the natural selection process B - cells undergo each time they encounter a new pathogen.

This natural selection process results in a B - cell that binds almost perfectly.

Cancer cells are no exception, and are subject to the two overarching mechanisms described by Charles Darwin: chance mutation and natural selection.

Combing the genetic data from a transmission study in ferrets, a team led by Thomas Friedrich, a professor of pathobiological sciences at the University of Wisconsin - Madison School of Veterinary Medicine, found that during transmission, when one animal is infected by another through sneezing or coughing, the process of natural selection acts strongly on hemagglutinin, the structure the virus uses to attach to and infect host cells.

This affords safe passage to a theoretically unlimited selection of carriers targeting distinct cell surface receptors.»

All cancers are products of natural selection played out on the level of cells rather than species.

To become a full - blown cancer (as opposed to a cell with a single, potentially threatening mutation — a genetic risk factor for becoming a cancer) requires the accumulation of five to ten mutations, and statistically that requires multiple rounds of cell division and selection.

In addition to providing insights regarding selection of treatment, this blood test may also prove helpful in assessing the presence of residual disease, recurrence, or relapse and detection of therapy - resistant cancer cells more quickly than conventional tissue - based methods.

«FDG PET shows tumor DNA levels in blood are linked to NSCLC aggressiveness: Insights derived from FDG PET could improve treatment selection for patients with advanced non-small cell lung cancer.»

It also includes an imaging station and CellSelect software, which images each nanowell and provides automatic selection of single cells for downstream processing.

The lab, at times, feels like a seething primordial soup of Darwinian selection, where only the strongest survive (i.e., publish papers in Science, Cell, or Nature), and the weak fade into oblivion (i.e., become anorexic, turn into technical sales reps, or go to law school).

If the antigen receptor binds a body molecule too tightly, the developing T cell might eventually cause an autoimmune disease; in this case negative selection is triggered, and the cell dies.

Despite strong selection against the sickle - cell gene, 10 to 20 percent of Africans are carriers.

A renowned neuroscientist sees ideas of selection as describing the honing of connections among brain cells.

He is also concerned about China, which prohibits gene - editing of embryos but does not strictly enforce similar rules, as shown by failed attempts to curb the use of ultrasound for sex selection and to stamp out unauthorized stem - cell clinics.

The generation of the germinal centers requires B cells to undergo a complex transcriptional program to allow them to divide rapidly, modify their antibody genes, and pass through a selection procedure that induces either their survival or their death.

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

Utilizing a kind of natural selection, the immune system chooses the cell line that is highly equipped to deal with an environmental challenge.

Conservation work to defeat the disease has including removing infected individuals from the population and new research in Evolutionary Applications explains how this gives us a unique opportunity to understand how human selection alters the evolution of cancerous cells.

Xie and his colleagues took the cells through three of these selection rounds — each requiring about ten days of working and waiting — but saw dismayingly few signs of progress.

For the new study, the team set out to do a proof - of - principle selection of antibodies that can bring about a different effect: protecting cells against an otherwise certain death.

Once donor blood cells mix with recipient immune cells, they blunt the immune attack by a process called negative selection, says Strober, who has spent 30 years developing the regimen.

The team plans to test the approach in a clinical trial in which chemotherapy drug selection for each person will be guided by testing balls of their tumour cells in the lab.

In negative selection, the thymus presents proteins from foreign tissue to immune cells, in effect asking them, «Do you recognise this material?»

And on page 1693, another team reports further evidence of the action of natural selection in people: A gene expressed in microglia, immune cells of the nervous system, produces a protein found only in humans.

The classic theory to explain the evolution of different size sex cells and therefore different sexes is the Disruptive Selection Theory and was proposed in the 1970s.

«Importantly, fighting a pathogen by hitting an enzyme from the host cell is likely to slow the emergence of drug resistance, because the pathogen can not easily escape through the selection of target mutations,» Professor Doerig said.

The percentage of cells expressing both E-selectin and VCAM - 1 (or DiI - Ac - LDL for bone - derived cultures) after 5 h of TNF - α stimulation in the second series of selection increased significantly to reach values of 30 — 40 % for most cultures.

To learn more about this research, please view the full research report entitled «Regulated selection of germinal center cells into the memory B cell compartment» at this page of the Nature Immunology website.

But this selection method has one drawback: it determines an antibody's ability to activate a desired biological pathway in a cell by measuring the resulting proliferation of that cell — a slow and only narrowly applicable indicator.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

One of the primary objectives of this study was to establish a protocol to facilitate the identification and selection of microvascular endothelial cells from primary organ cultures with a high degree of precision.

Phase - contrast images of organ - derived endothelial cells (37 °C culture conditions) that had undergone two successive selection processes by flow cytometry.