Sentences with phrase «ips cell differentiation»

The type of found cell is thought to influence the efficiency of iPS cell differentiation to blood cells, with blood founder cells being best.

Not exact matches

Yamanaka's group and two others followed up earlier this year with firmer evidence that these induced pluripotent stem (iPS) cells faithfully mimicked the patterns of gene activity and cellular differentiation observed in embryonic stem cells.

Wu, who is also a professor of cardiovascular medicine and of radiology, said, «This study certainly makes us optimistic that differentiation — into any nonpluripotent cell type — will render iPS cells less recognizable to the immune system.

These findings reveal molecular factors that can be used to evaluate the differentiation potential of different cell lines, which should expedite the progress of iPS cells to clinical use.

Another factor that could also contribute to the efficiency of iPS cell line differentiation is the method with which the iPS cells were made.

Indeed, we have obtained a homogenous mesodermal cell populations derived from human pluripotent stem cells (hES and iPS cells), which could represent discreet differentiation steps.

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using our novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals models.

Human iPS cell - derived hepatocytes differentiated with our robust differentiation protocol and cultured using a novel maintenance medium provide an inexhaustible, consistent supply of functional hepatocytes that can be used to advance the understanding of diseases related to dysfunction in liver metabolism, including NAFLD / NASH, type 2 diabetes, and metabolic syndrome.

«This collaboration combines Dr. Yamanaka's human iPS cells and Novocell's hES cell differentiation and encapsulation technologies to explore the creation of next generation diabetes cell therapies,» said Emmanuel Baetge, Chief Scientific Officer of Novocell, Inc..

(c) The ratio of beating EBs in directed differentiation of iPS cells of line 11.1 into cardiomyocytes was shown.

In this study, we analyzed three different cultures of neural cells carrying trisomy of chromosome 21, which were generated by directed differentiation from induced pluripotent stem cells (iPS cells).

Interestingly, cells from both iPS cell lines expressed early cardiac differentiation markers and transcription factors, implicating that there could be a lack in functional cardiomyocyte maturation in line 4.1.

The early cardiac markers and transcription factors (Gata4, Mef2c, Hind I, Nkx2 - 5 and beta - Mhc) were examined in iPS cell lines 11.1 and 4.1 during the cardiac differentiation process (differentiation day 0, day 3, day 6 and day 9).

(C) Directed differentiation of iPS cells of line 11.1 into neural lineages.

For monolayer differentiation, confluent iPS cells were cultured in the HFF culture medium without any growth factors.

A team led by Donald Ingber, Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Founding Director of Harvard's Wyss Institute of Biologically Inspired Engineering, now reports a solution to this challenge in Nature Biomedical Engineering, which enables the differentiation of human induced pluripotent stem (iPS) cells into mature podocytes with more than 90 percent efficiency.

Signaling pathways / factors regulating and / or initiating ESC / iPS cells pluripotency and differentiation

Here we report the differentiation of human iPS cells into RPE.

The successful differentiation of iPS cells into RPE represents a significant advance in the search for a potential cell source for the treatment of human neural retinal diseases.

Through genome - wide profiling we find that 5 - 46 % of the variation in different iPS cell phenotypes, including differentiation capacity and cellular morphology, arises from differences between individuals.

iPS (IMR90)-3 cells readily differentiate into RPE cells and the differentiation protocol used in this paper is a highly efficient method of producing multiple confluent flasks of highly enriched pigmented cells.

iPS - RPE also down - regulate the embryonic transcription factors originally used to induce pluripotency from the somatic cell [18], suggesting differentiation away from the initial iPS phenotype.

378/11: 15 Smith - Lemli - Opitz Syndrome iPS cells demonstrate abnormal neuronal differentiation due to 7 - dehydrocholesterol impairment of Wnt / β - Catenin signaling.

By developing a simple chemically defined culture system permitting efficient differentiation of numerous human iPS cell lines toward cells of a mature hepatic state, we now demonstrate the possibility of modeling groups of diseases of non-neuronal origin whose phenotypes are a consequence of complex protein dysregulation within adult cells.