Sentences with phrase «ips cell donors»

However, Takebe's liver bud has the advantage of being grown from iPS cells, rather than, for example, the primary human hepatocytes used in Bhatia's graft, which could make it useful in modelling rare diseases or examining the specific genetic backgrounds of the iPS cell donors.

Not exact matches

Regulatory changes, under which the Japanese government allowed the distribution of iPS cells for clinical use, also prompted researchers to switch the study to a more efficient process of using cells from third - party donors instead of using a patient's own cells.

Hsiao and colleagues carefully gathered skin samples from donors, and then grew the skin cells in culture before converting them into iPS cells using the methods created by Yamanaka.

The far - reaching potential of iPS research, combined with a higher likelihood that cell lines will stay linked to a single donor (and that donor's health history), heightens the need for consensus, said Timothy Caulfield, research director of the Health Law Institute at the University of Alberta in Edmonton.

Some ethicists suggest that tissue donors deserve a share of the tremendous commercial potential of iPS cell lines as disease models, drug - testing platforms or treatments.

And how will a disillusioned cell donor withdraw when iPS cell lines have been distributed all over the world?

Donors might share in some monetary rewards and be able to opt out of certain uses for iPS cells, such as for creating gametes or mixed species, or have a say in the overall direction of research, Solbakk suggested.

The embryo used to derive an ES cell is not genetically identical to the donor of the cell that is transformed into an iPS cell, so researchers expect some discrepancies in gene activity.

The fact that the researchers made their iPS cells from cells that matured in the lab from ES cells, instead of from the cells of a patient or donor, means that they still might carry traces of the ES cells» gene activity patterns.

Then he compared them with neurons made from iPS cells that originated from a healthy donor.

And iPS cells may have a particular advantage: Taking a person's own skin cells, say, making them pluripotent, and then using those cells to grow whatever kind of tissue is needed could eliminate the use of debilitating immunosuppressive drugs, which are required when transplanting cells or tissue from a donor.

Donor cells of iPS cells of line 4.1 were from black mice (C57 BL / 6J).

Therefore, it is necessary to establish multiple independent iPS cell lines from individual donors to ensure efficient generation of various types of functional cells for future application in the treatment of diseases.

The absence of iPS - RPE cells in the subretinal space at the time of functional assessment (13 weeks) indicates that the significant benefits observed could not be wholly attributed to the donor cells.

The increased visual acuity and outer nuclear layer preservation observed in iPS - RPE injected animals could also be due to a neuroprotective effect produced by the donor cells.