Sentences with phrase «ips cell state»

Not exact matches

It has become clear that iPS cells can retain some memories of their previous state.

The moral complications of the new state of the art go even deeper, due to an advance that scientists anticipate within a decade: using iPS cells to create human sperm and egg cells.

Avoiding the pluripotent state is important because it avoids the potential danger that «rogue» iPS cells could develop into a tumor if used to replace or repair damaged organs or tissue.

In a study published in October 2008, Melton showed that it was possible to take an exocrine cell in the pancreas of a live mouse and turn it into an insulin - producing beta cell without first going back to an undifferentiated iPS state.

Rather than reversing cells all the way back to a stem cell state before prompting them to turn into something else, such as in the case of iPS cells, the researchers «rewind» skin cells just enough to instruct them to form the more than 200 cell types that constitute the human body.

Critical issues include: (i) heterogeneity in stem cell populations (ii) regulation of cell fate choices; (iii) declining tissue performance with age and exposure to environmental injuries; (iv) the use of iPS and Embryonic Stem (ES) cells, and reprogramming methods for phenotyping disease states and potential use of these stem cells in the clinic.

However, while hESCs are created from human embryos, iPS cells are cells that were originally from adult tissues, such as skin from an adult body, but have been «reprogrammed» to a hESC - like state.

All of these data highly support that iPS cells derived from hNSCs can be reprogrammed to a hESC - like state at the molecular level.

In light of the observation that iPS cell derivation takes place under the same culture conditions used for ES cells [20], we hypothesized that these human feeder cells could offer a stable tool for defining molecular hallmarks during conversion of differentiated somatic cells to the pluripotent state.

Transgenes are inactivated and the endogenous Oct4 promoter is completely demethylated in the established iPS cell lines, indicating a fully reprogrammed state.

In addition, their independence of LIF for iPS cell culture provides an opportunity to further understand the ground state of ES cell self - renewal proposed by Ying et al. [21].

And at Japan's RIKEN Center for Developmental Biology, one pioneering group is taking induced pluripotent stem cells (iPS), mature cells reprogrammed to return to a state of pure potential, and turning them into RPE cells.

In addition, scientists are working to identify the molecules that instruct iPS cells to adopt a certain state, which could improve their use for regenerative medicine.

For cell reprogramming, there are about 2,000 known transcription factors that might be useful in changing a cell from one state to another, such as creating induced pluripotent stem (iPS) cells from skin cells.

* Correction: An earlier version of this story incorrectly stated that Yamanaka did not genetically manipulate the skin cells used to make iPS cells in 2006.

By developing a simple chemically defined culture system permitting efficient differentiation of numerous human iPS cell lines toward cells of a mature hepatic state, we now demonstrate the possibility of modeling groups of diseases of non-neuronal origin whose phenotypes are a consequence of complex protein dysregulation within adult cells.