Not exact matches
He notes his company had planned this year to apply to the U.S. Food and Drug Administration to use red
blood cells and platelets derived
from iPS cells in clinical trials, but «at this point, therapies with these
cells are years off.»
In a related paper published online today in Nature Biotechnology, Konrad Hochedlinger of the Harvard Stem
Cell Institute in Cambridge and his colleagues compared the gene expression patterns in mouse
iPS cells derived
from white
blood cells, muscle precursor
cells, immune system
cells called B
cells, and fibroblasts taken
from tail tips.
For instance, CiRA's Kohei Yamamizu recently reported developing a cellular model of the
blood — brain barrier made entirely
from human
iPS cells.
Although embryonic stem
cells are naturally pluripotent,
iPS cells are created by scientists
from existing adult
cells, such as skin or
blood.
Blood from mice treated with
iPS cells (above) does not show the sickle - shaped
cells present in untreated mice (top).
We can obtain
iPS cells from an individual's skin or
blood and program them into different tissue types to create patient - specific Organ - Chips.
Blood cells derived
from iPS cells also have other obstacles: an inability to engraft into organs or bone marrow and a likelihood of developing tumors.
Efficient human
iPS cell derivation by a non-integrating plasmid
from blood cells with unique epigenetic and gene expression signatures.
Standardize and scale up production of identical induced pluripotent stem (
iPS)
cells, which are stem
cells made
from an individual's own skin or
blood cells.