Not exact matches
Bacteria
expressing enzyme in one
cell (bright green), while genetically
identical cells do not, remaining protected from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded with resistance to antibiotics built right into their genes.
A famous example of how transcription factor expression can be used to alter a
cell's identity is the creation of iPSCs, where adult
cells were forced to
express transcription factors normally
expressed in ESCs, which made the adult
cells express genes specific to ESCs, and consequently become nearly
identical to ESCs.
By making
cells express these embryonic stem
cell proteins, adult
cells can be created that look and act nearly
identical to hESCs.
Moreover,
cells expressing the V617F / Y931C double JAK2 mutant showed
identical sensitivity to the inhibitors as
cells expressing Y931C mutant alone, with a 20 to 50-fold increase in the IC50 (INCB018424 and CMP6, respectively) compared to V658F mutation - positive
cells.
Importantly,
cells expressing the double mutants V658F / F958C showed
identical sensitivity to the inhibitor as
cells expressing F958C mutant alone (Online Supplementary Figure S3B).