Sentences with phrase «identification of genetic»
Identification of a genetic link enables breeding programs to minimize passage of this defect to future generations.
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Her work has led to the identification of genetic mutations for heart disease in companion animals; and development of clinical management recommendations, including for feline cardiomyopathy in Maine coon and ragdoll cats, boxer dog cardiomyopathy and, most recently, long QT syndrome in English springer spaniels.
The creation of a panel of DNA tests for Tibetan Terriers may also lead to breakthroughs in the identification of genetic mutations that cause rare diseases in Tibetan Terriers.
The identification of the genetic mutation now enables breeders to correct the problem.
12/2: 45 Improved identification of the genetic basis of disease by integrated analysis of RNA - seq together with whole - genome and exome - based sequencing data.
The rapid identification of genetic risk factors for common, complex diseases poses great opportunities and challenges for public health.
The identification of the genetic mechanisms underlying human - specific brain development during evolution will transform our ability to decipher the pathophysiological mechanisms underlying neurodevelopmental disorders affecting humans such as autism or schizophrenia.
Our main goal in this project is to use NGS in identification of genetic causes of rare / ultrarare early - onset neurologic diseases, integrating «omics» platforms with systematic approaches to enrich and redefine phenotypic ontology in these conditions, allowing a comprehensive analysis of genomic data.
In the last decade the identification of genetic drivers of melanoma cell which regulate proliferation and survival - such as BRAF and other activators of the MAP - kinase pathway - along with the recent development of immunotherapy has taken away in many cases the invasive treatment of melanoma as an option.
Modern molecular technologies (genomics and other omics), through comparing nucleic acid and amino acid sequences across living species, are enabling the identification of genetic components and patterns stingily conserved by evolution, from those in which times of evolutionary branching of the tree of life can be inferred.
This study was selected for the Trainee Paper Spotlight because it uses multiple techniques to understand disease pathophysiology from identification of genetic variants to evaluation of their role in disease pathogenesis.
His research interests include the molecular underpinnings of cervical cancer (including developing genetic screens), the identification of the genetic determinants of quantitative traits in humans, and the application of massively parallel sequencing technology for understanding the genetics of complex disease.
The advance, described in next month's issue of Nature Biotechnology, could lead to more accurate screening of organ donors and identification of genetic targets for new drugs.
Dr. Seshadri, founding director of the Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases at UT Health San Antonio and holder of the university's Robert Barker Distinguished University Chair, said the identification of genetic regions that are strongly correlated to stroke will increase potential targets for stroke drug development.
«This work marks, to the best of our knowledge, the first identification of a genetic basis for a mast - cell - mediated urticaria induced by a mechanical stimulus,» said Dean Metcalfe, M.D., chief of NIAID's Laboratory of Allergic Diseases and a study co-author.
While the means to cure some conditions may take years to develop, identification of genetic markers can lead to early treatment.
The result: a host of docile foxes and the identification of the genetic underpinnings for their domestication.
The identification of these genetic defects has fed back to create ever more realistic animal models of the diseases, as mentioned earlier for Huntington's disease.
Not exact matches
New genetic forensics techniques emerged from the identification of 9/11 victims, for example.
These genes are implicated in highly penetrant genetic disorders for which surgical or other interventions aimed at preventing or significantly reducing morbidity and mortality are available to pathogenic variant carriers.5 Identification of a pathogenic variant in one of these genes could be diagnostic of a medical condition with potential implications for an individual's medical management.
For a provocative look into the world of genetic testing and talent identification, Farrey went to Australia with a cheek swab to get his one - year - old son screened for athletic traits.
It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.
O. M. Pereira - Smith and J. R. Smith, Genetic analysis of indefinite division in human cells: Identification of four complementation groups.
According to Dr. Philip Awadalla, senior author and principal investigator, «the fact that two very close populations (French versus French Canadians) accumulate such an excess of differences in rare variants has important consequences in the design of genetic studies, including the identification of possibly damaging mutations associated with diseases specific to this population.»
Identification of a specific genetic mutation in patients with non-small-cell lung cancer (NSCLC) helps clinicians select the best treatment option.
«Better assessment of teens» ability to concentrate could facilitate the identification of those at risk of anxiety and could also inform molecular genetic studies, which would be the logical next stage for research.»
genetic studies that led to the identification of potential sources of B. anthracis recovered from the letters;
The barley genome sequence also enabled the identification of regions of the genome that have been vulnerable to genetic bottlenecking during domestication, knowledge that helps to guide breeders to optimize genetic diversity in their crop improvement efforts.
Even with the advent of DNA sequencing and genetic identification, this was generally done with one particular ribosomal gene.
This is one of the largest documented hunts of dolphins in the world, rivaling even the more - industrialized hunting of dolphins in Japan, noted Baker, whose genetic identification research was featured in the Academy Award - winning documentary on dolphin exploitation, «The Cove.»
An improved and expanded nomenclature for genetic sequences is introduced that corresponds with a ranking of the reliability of the taxonomic identification of the source specimens.
«Consequently, in the current state of knowledge, no child or young athlete should be exposed to [direct to consumer] genetic testing to define or alter training or for talent identification aimed at selecting gifted children or adolescents,» it concludes.
We hope that the identification of these new genetic factors will speed progress towards truly personalised medicine.
The current research findings build upon recent discoveries including novel identification of key genetic changes in cells of the immune system.
«The identification of HPV - negative endometrial - like tumors confirms that not all cervical cancers are related to HPV infection and that a small percentage of cervical tumors may be due to strictly genetic or other factors,» noted Jean - Claude Zenklusen, Ph.D., director of NCI's TCGA program office.
«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.
«Identification of yet another genetic cause for this neurodegenerative disorder will allow for better genetic testing and counseling to families with an affected child,» he said.
The research team took a small blood sample during one of Sequoia's routine physicals and extracted enough DNA to get a clear understanding of her genetic identification.
Genetic identification of spotted owls, barred owls, and their hybrids: legal implications of hybrid identity
For their seminal contributions to concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics.
• Mouse whole genome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic software.
The Woodlands, Texas — May 11, 2006 — Lexicon Genetics Incorporated (Nasdaq: LEXG) announced today that it was awarded a grant from the United States Army Medical Research & Materiel Command (USAMRMC) for the identification of targets that may be important in the development of drugs to prevent or treat spinal muscular atrophy (SMA), a neurodegenerative disorder and the leading genetic cause of death in early childhood.
In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.
All experiments involving mice were judged and approved by the national committee for genetic identification of organisms and the animal ethical committee, and were conducted according to national and international guidelines.
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
The limited genetic diversity of dog breeds facilitates identification of genes, functional variants and regulatory pathways underlying complex psychiatric disorders that are mechanistically similar in dogs and humans.
Bruce A. Beutler establishes the genetic basis linking toll - like receptor 4 (TLR4) to the identification of microbes.
«SMA is a grave and life - threatening condition, but it is the genetic disorder that is most promising for therapeutic target identification,» said Darryl C. De Vivo, MD, Sidney Carter Professor of Neurology and Pediatrics, and Co-Director of the Center for Motor Neuron Biology and Disease at Columbia University Medical Center.
The characterization of the genetic alterations observed in neuroblastoma led to the identification of major players of neuroblastoma oncogenesis that has considerably improved our understanding of the biology of this pediatric cancer.
Her current research is focused on the identification of genes and molecular pathways for rare disorders and she is the Lead Investigator of the Genome Canada, CIHR funded «Finding of Rare Disease Genes in Canada» (FORGE Canada) and «Enhanced CARE for RARE Genetic Diseases in Canada» initiatives.