Sentences with phrase «identified candidate genes»

Analysis of polymorphic microsatellites showed that the regions flanking COLQ are IBD, whereas those flanking the other 2 identified candidate genes are not.

University of Illinois researchers have identified candidate genes controlling the accumulation of phenolic compounds in broccoli.

University of Illinois researchers have identified candidate genes controlling the accumulation of phenolic compounds in broccoli.

A team led by Margaret Pericak - Vance of Duke University, Jonathan Haines of Vanderbilt University in Nashville, Tennessee, and Allen Roses — a former Duke researcher now in charge of genetics research at the Glaxo Wellcome Company in Research Triangle Park, North Carolina — scanned the DNA of members of 16 large families with a high rate of Alzheimer's, looking at 280 genetic markers that might help identify candidate genes.

An active international research has been carried out for several years in order to identify candidate genes which explain the origin and development of the disease.

Johannessen et al. used a highly systematic approach to identify candidate genes and signaling networks that contribute to resistance.

However, if the purpose of such a scan is to identify candidate genes, then — as with single - gene studies — more detailed follow - up and functional validation of at least some of the key genes of interest are necessary to shore up the evidence.

This study is designed to determine the incidence of BCSL in the breed, to determine the mode of inheritance if a single gene is involved, and identify candidate genes for further investigation.

Not exact matches

We identify key candidate genes that may control rate - limiting steps during lactation and outline future work in the endeavor to discover the biological underpinnings of poor lactation performance in women attempting to breastfeed.

To generate a rich source of potential vaccine and drug target candidates, the team identified a set of genes that are more active in certain stages of the parasite life cycle and within the parasite's gut.

«We have identified a series of about 100 candidate genes that could explain the ability of animals to rapidly respond to fluctuating temperatures.»

«Identifying which of these candidate genes actually causes variation in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics in the Division of Biology at Kansas State University and senior author of the study.

«Essentially, we are using the human placenta as a model to identify genes that play a key role in invasion in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D. candidate leading the project, in an email.

Predisposition to vascular disease was my focus here, using genetic epidemiological studies to identify novel polymorphisms in a range of candidate genes.

After gene mapping we had several candidate regions to choose but exome sequencing quickly identified the actual mutation.

We plan to take the candidate genes we identified here and use them in a breeding program to improve the health benefits of these vegetables.

Using previous data, Orkin and his team identified the BCL11A gene as a candidate for controlling the molecular switch.

The new candidate myeloma genes we identified in the African - American population may have been overlooked because of the lack of diversity in previous genomic efforts.»

Published Dec. 18, 2017 in Nature Genetics, a team led by researchers at Joint Genome Institute (JGI) and the Howard Hughes Medical Institute at the University of North Carolina at Chapel Hill (UNC) have exploited a catalog of bacterial genomes to identify and characterize candidate genes that aid bacteria in adapting to plant environments, specifically genes involved in bacterial root colonization.

Published December 18, 2017 issue in Nature Genetics, a team led by researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility, and the Howard Hughes Medical Institute at the University of North Carolina at Chapel Hill (UNC) have exploited a catalog of bacterial genomes to identify and characterize candidate genes that aid bacteria in adapting to plant environments, specifically genes involved in bacterial root colonization.

«Importantly, the team was able to identify several genes that may be able to help us to predict outcomes in certain circumstances or serve as good candidates for therapeutic efforts.»

The study, which has identified more than 200 rare variants inherited by children, determines that genes YWHAZ and DRP2, among others, are new candidates in the research on autism genetic basis.

A traditional way to target a candidate gene is to identify a molecule or process important to, say, emotion, and then go back and find the genes that control it.

Lynch and his colleagues are now identifying candidates for other mammoth genes to functionally test as well as planning experiments to study mammoth proteins in elephant cells.

Then, they estimated enrichment factors by determining how frequently those known cancer - associated genes occurred among the top gene candidates identified by different analysis methods.

Using methods for analyzing gene expression in mice, they identified several members of the «BMP» family of proteins from among more than 20,000 possible candidates.

VAAST, also developed in Yandell's laboratory, identified a number of mutations that might have caused the syndrome, but couldn't identify an individual candidate as the causative gene.

By combining those factors, Phevor identifies an undiagnosed disease or the most likely candidate gene mutation for causing a disease.

The researchers then identified children, among other families, who carried the single candidate gene.

This visual abstract of Mohammad et al. depicts how mammalian anxiety factors also govern defense behaviors in the fly and use these behaviors to identify new conserved candidate anxiety genes.

Cd14 is involved in the detection of bacterial factors and has been identified as a candidate gene in genetic screens.

«These findings suggest that focusing on genes with conserved expression levels among primates may be helpful in identifying promising candidates for disease - association studies,» the researchers write.

A companion paper published in BMC Evolutionary Biology by colleagues at the EPA lab in Narragansett, RI, that used a «candidate gene scan» approach — examining SNPs from 42 genes associated with the AHR pathway — also identified AHR2 as a gene that appears to be under selection and is likely to be involved in the resistance.

The analyses identified 17 candidate genes that might be related to aging in the DG.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

«Our research team is the first to describe a high - throughput in vivo validation system to screen candidate disease genes identified from patients.

However, more studies are needed to dissect the role of the candidate regions and genes identified in selection regions,» says Järvelä.

Let's say that you've identified a new possible cancer susceptibility gene, a candidate tumor - suppressor.

Candidate gene and genome - wide association studies have identified variants associated with HBV - related disease progression or hepatocellular carcinoma in various populations [46][52].

To find out if such a gene - environment interaction is involved, they first identified a likely candidate gene, FADS2, which codes for an enzyme known to play a key role in fatty acid production.

In addition to SIRT1, they identified three candidate genes that ApoE4 seems to repress: two are anti-inflammatory, one is antiapoptotic.

Candidate genes and functional noncoding variants identified in a canine model of obsessive - compulsive disorder.

The researchers particularly identified three novel candidate genes; KIRREL3 and SLIT1, with documented roles in immune cell development, and SERPINA9 expressed exclusively at the site (germinal center) where a B - cell starts producing IgA.

Perform phenotypic profiling in primary human cells to identify and characterize candidate genes with therapeutic potential,

Novel candidate genes have been identified and the results are published in PLOS ONE.

As mRNA isolation is simple and since DNA microarrays are a proven genomics reagent for monitoring differential gene expression, a genome - wide expression analysis may be the fastest and most efficient method for identifying additional candidate effectors of colony queen number.

Gene - expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic.

They identified 10 candidate genes in the hypothalamus, an area of the brain which helps regulate anxiety.

In the sequencing of five candidate genes (LPL, LCAT, ABCA1, PON1, and SERPINE1), rare and common SNPs were identified that were associated with differences in serum lipids.

We also examined whether candidate genes for T2D and / or obesity, previously identified by GWAS (P < 1.0 × 10 − 5 [www.genome.gov/gwastudies]-RRB-, exhibit differential methylation in adipose tissue of unrelated patients with diabetes versus nondiabetic subjects.