We have
identified common alleles of genes that contribute significantly to both of the principal processes involved in obesity — basic energy metabolism on the one hand and the regulation of appetite on the other,» said Kari Stefansson, CEO of deCODE.
Not exact matches
To
identify common functional variants, the authors used an allelic transmission disequilibrium test (TDT), which determines if an
allele is transmitted more (or less) than we'd expect by chance.
Performing genetic studies in multiple human populations can
identify disease risk
alleles that are
common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease
alleles.
These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating
alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most
common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been
identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.
Thus,
identifying one of these
common alleles would not have the same implications for medical management as would finding a pathogenic mutation in BRCA1 or BRCA2.