«For the first time, our study
identified detailed gene expression levels in these granules.
Not exact matches
In many animal model systems, for example, the precise
genes involved in sexual partner selection have been
identified, and their neuro - biochemical pathways have been worked out in great
detail.
«By
identifying the full set of
genes in each of these two cell types, we provide
detailed information that taste scientists can use to help understand how these cells work, both when healthy and also when affected by damage or disease.»
Detailed analysis
identified the
gene responsible for this trait.
The three stages of CD8 + T cell development are well known, but the current study
identifies a
detailed map of the regulatory circuitry, such as interactions between enhancers and promoters — genetic regulatory regions that function together in driving
genes to transcribe proteins to carry out biological processes.
The deCODE team, working with doctors and researchers at Iceland's National University Hospital and the Icelandic Heart Association,
identified the PDE4D
gene and significant haplotypes by analyzing
detailed genotypic data from some 1800 participants in its stroke program, both patients and unaffected relatives, from across Iceland.
Ohsumi and his students, postdocs, and collaborators have had an outsized influence on this field, not only in
identifying the
genes that underlie cellular recycling, but in revealing many of the molecular
details of how these players function.
Hence, as we gain more
detailed knowledge, the pipeline may continuously incorporate new
genes and pathogenic variants,
identified through postnatal WES investigations in severely affected newborns and children.
For more information see the
detailed Mendelian Traits by the Numbers report, list of phenotypes studied, and disease
genes identified, by the CMGs and a listing of CMG presentations.
Funding Agency NIH NCI Title Improving etoposide treatment of Ewing's sarcoma Status Active Active Period 9/2011 -7 / 2016 Role Principal Investigator Grant
Detail To
identify genes involved in surviving etoposide exposure and to determine the utility of targeting these
genes to improve etoposide treatment of Ewings sarcoma.
However, if the purpose of such a scan is to
identify candidate
genes, then — as with single -
gene studies — more
detailed follow - up and functional validation of at least some of the key
genes of interest are necessary to shore up the evidence.