«We have already observed that gene egr - 4 is regulated by the
epidermal growth factor receptor (EGFR) signaling pathway, so it will enable to
identify also the
factors that activate this pathway during anterior regeneration.
In addition to RIPK2 binding as part of this computer - based (initial) screening, we selected compounds that inhibited
epidermal growth factor receptor (IC50 values > 1000 nM; weak inhibitory activity) along with weak binding interactions in the EGFR and c - ABL binding sites, two common off - targets for previously
identified RIPK2 inhibitors.