Sentences with phrase «identified fibrinogen»
«Not only did we confirm that the presence of blood in the brain recruits peripheral immune cells to the area, which is sufficient to cause myelin destruction, we also identified fibrinogen as the critical protein driving this process.»
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Application of high - throughput screening to identify a novel αIIb - specific small - molecule inhibitor of αIIbβ3 - mediated platelet interaction with fibrinogen.
Her aim is to understand, at the molecular level, the mechanisms that control communication between the brain, immune system, and blood vessels — with the ultimate goal of designing new therapies that slow, stop, or reverse the progression of a wide range of neurological disorders, such as MS. Recently, Dr. Akassoglou's lab identified how microglia — a type of immune cell that acts as the brain's first line of defense — are activated when fibrinogen enters the brain or spinal cord.
She also identified a potential way to block the damaging effects of fibrinogen as it enters the brain while allowing it to maintain its ability to clot blood.
The work highlights the importance of fibrinogen - erythrocyte interactions in patients with chronic heart disease, and our technique can be used to identify patients at higher risk for this disease,» he tells nanotechweb.org.
Our scientists have also pointed the way to a new therapeutic strategy for multiple sclerosis and other neurological diseases by identifying that a blood protein, fibrinogen, plays a causal role in damaging the central nervous system.
«Importantly, this analysis helped us identify the protein fibrinogen as the key culprit in MS, by demonstrating how its entry into the brain through leaky blood vessels impacted the health of individual nerve cells.»