Sentences with phrase «identified key genes»

Further, Shankman identified a key gene, Klf4, that appears to regulate these transitions of smooth muscle cells.

They had identified a key gene in the beet cyst nematode that makes the cytokinin hormone.

«In mammals, in the absence of haploid cells, other approaches have been used to identify key genes, such as interfering RNA, but they are sub-optimal methods.

The data allowed the researchers to generate personalized genome - scale metabolic models for cancer patients to identify key genes involved in tumor growth.

«What is more, the technique identifies key genes and enriched gene ontology pathways, as well as categories related to stem cell differentiation — and specifically toward osteochondral lineages (that is, related to bone and cartilage tissue growth).»

Researchers identify a key gene that allows C. difficile — a diarrhoea - causing bacterium found in hospitals and across the developing world — to be transferred from person to person [Image Credit: CDC / Dr.

Researchers identify a key gene that allows C. difficile — a diarrhoea - causing bacterium found in hospitals and across the developing world — to be transferred from person to person [Image Credit:...

Not exact matches

We identify key candidate genes that may control rate - limiting steps during lactation and outline future work in the endeavor to discover the biological underpinnings of poor lactation performance in women attempting to breastfeed.

With new tests to identify women who are at heightened risk of breast cancer, new drugs aimed at preventing allergies, and the discovery of new genes that are key to the progression of conditions like Alzheimer's - to give just three examples - we are at the dawn of a whole new era:

«The advantage of being able to adjust a set of genes identified as key autism risk factors may explain the strong and long - lasting efficacy of this therapeutic agent for autism.»

«Essentially, we are using the human placenta as a model to identify genes that play a key role in invasion in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D. candidate leading the project, in an email.

This image shows the metabolic expression of a gene identified by scientists from EPFL in Lausanne and ETH Zürich as being a key player in the development of type 2 diabetes.

In recent years, clock researchers have uncovered some of the gears and springs that keep this circadian timepiece running, largely by identifying a handful of key genes in organisms from bread mold to mice.

For the first time, the response of more than 10,000 genes was followed simultaneously, which identified brassinosteroids and auxins and their signalling molecules as key to the growth stimulation observed in biochar.

Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

So some researchers have started with clinical mutations that impair key traits, then traced the genes» evolution, an approach that has identified a handful of tantalizing genes.

Genomics - based discovery is key for identifying genes of potential interest to plant breeders and biotech seed developers.

Lahn and his colleagues looked at the abnormal spindle - like microcephaly associated (ASPM) gene, which scientists had previously identified as a key player in brain development.

Scientists have identified genes that are active during puberty, but most also have key functions in other basic processes, such as regulating fat.

The study identified five genes predictive of feeding success representing a range of biological systems: sensory integration (NPHP4, PLXNA1); hypothalamic regulation, a region of the brain that plays a key role in hunger signaling (NPY2R); facial development (WNT3, a gene associated with lip and palate development); and energy expenditure (AMPK, a regulator of whole body energy balance).

They then identified the putative causal mutations in genes controlling shattering (a key domestication trait among cereal crops).

«Scientists identify proteins crucial to loss of hearing: Proteins play key role in genes that help auditory hair cells grow.»

The map is a key tool that geneticists rely on to find disease genes and identify the functional genetic variations at the core of human diversity.

She notes that a few of the genes the team identified code for glutamate receptors, which play a key role in learning and memory and may have been selected in humans as well.

With funding from Wine Australia, a team of scientists from the ARC Centre of Excellence in Plant Energy Biology at the University of Adelaide and CSIRO Agriculture and Food identified genes expressed in grapevine roots that limit the amount of sodium — a key component of salt — that reaches berries and leaves.

After analyzing brain tissue samples, the researchers identified an area of the gene where a single change reduced BDNF levels in the hypothalamus, a key area that controls eating and body weight.

A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes.

A key step in this process is to compare symptoms identified by clinicians, such as neurodevelopmental delay or abnormal growth, with an in - house database of all known genes associated with developmental disorders.

Germany's Max Delbrück Center for Molecular Medicine (MDC) Berlin Buch and the Fu Wai Hospital of the Chinese Academy of Medical Sciences (CAMS) are building a new gene research laboratory in Beijing, the aim being to identify genes that play a key role in the pathogenesis of cardiovascular diseases.

Now, synthetic biologists have solved the last piece of the poppy puzzle, identifying the gene that controls a key intermediate step between the first and second halves of the process, which had already been sorted out.

In the new study, Srinivasan and her colleagues, first author Research Assistant Tallie Noble and graduate student Jonathan Stieglitz, used a series of gene - blocking experiments to identify some of the circuit's key elements.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

This gene, along with another size - governing gene called fw2.2, which Tanksley identified 10 years earlier, was the key step in making tomatoes a dietary staple.

The color - coded list identifies documented mutations in key viral genes, along with literature citations and a description of how the mutation is believed to change biological function.

Taking advantage of these «simplified» versions of melanoma, the researchers identified a dozen of new genes that are likely to play key roles in the initiation and / or progression of human melanoma.

A second project, dubbed Eumorphia, will organize more than a dozen labs in nine countries to systematically screen new mouse mutants for interesting characteristics — a key step in determining the function of newly identified genes.

Using cutting - edge molecular methods the research team identified 53 key genes that are involved in long - term, multi-generational acclimation to higher temperatures.

«By exploiting the unique nature of GAM data, mathematical models can reliably derive such information, opening the way to identify multiple, group interactions that could play a key role in the regulation of genes,» explains Nicodemi.

After the sections of DNA sequence have been assembled into a complete genome sequence we need to identify where the genes and key features are, but how do we do this?

Scientists at the Carnegie Institution have identified a gene, named scrawny, that appears to be a key factor in keeping a variety of stem cells in their undifferentiated state.

«The bioinformatics tools have matured to the point that we can now find the proverbial «needle in a haystack,» meaning we can now identify genes and pathways that are unique to pathogenic microbes, which will focus future research efforts on these key pathogen - specific features,» Fouts said.

We have identified several of the key genes and molecular genetic mechanisms that have contributed to such diversity.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

To find out if such a gene - environment interaction is involved, they first identified a likely candidate gene, FADS2, which codes for an enzyme known to play a key role in fatty acid production.

Scientists have now sequenced the genome of the Mexican axolotl, and have identified a few key genes hidden amongst its extremely complex genetic blueprint that shed some light on its remarkable regeneration capabilities.

The aim of this study is to identify potential key genes and pathways that are related to the calcification apparatus.

deCODE has identified key variations in the sequence of the genome conferring increased risk of major public health challenges from cardiovascular disease to cancer, and employs its gene discovery engine to develop DNA - based tests to assess individual risk of common diseases; to license its tests and intellectual property to partners; and to provide comprehensive, leading - edge contract services to companies and research institutions around the globe.

The Gladstone team had profiled changes in gene expression using DNA microarrays, which provides an unbiased method for identifying key biological pathways.