Sentences with phrase «identified mechanisms involved»

A leading expert in neural movement control, Jessell, a U.K. native who completed his Ph.D. at the University of Cambridge, conducted pioneering studies that identified mechanisms involved in the neural development and organization of the spinal cord.

Co-author Dr Lisa Leaver of the University of Exeter added: «By identifying the mechanisms involved in solving problems, we hope to better understand why there is so much variation between individuals and between species in these abilities.»

Researchers at Aarhus University, Denmark, have succeeded in identifying the mechanisms involved in what is known as the acid pump, which at the cellular level pumps acid into the stomach — in some cases leading to gastric ulcers and gastroesophageal reflux disease.

«There is only one other institution in the world taking this approach to identifying the mechanisms involved in natural tissue repair and regeneration.

Moving forward, longitudinal studies following the same subjects over time could help clarify whether olfactory loss directly influences social life and potentially allow the researchers to identify the mechanisms involved.

Not exact matches

Based on this work, the researchers identified a previously unknown regulatory mechanism in 2 - epimerase that involves direct interaction between one substrate molecule in the enzyme's active site and another in the enzyme's allosteric site.

The research identifies a potent mechanism — rapid evolution of the reproductive system — involved in speciation, says William Rice, an evolutionary biologist at the University of California, Santa Barbara.

«Given the similarities in the molecules and the mechanisms involved in limb development in vertebrates and invertebrates, the fly is a very useful genetic model in which to identify new genes that potentially participate in limb development in vertebrates and their possible association with congenital diseases,» says Ana Ferreira, who has participated in the study.

The main focus of their research was to identify causative mechanisms involved in the disease.

While Hazen's work revealed a variety of hydrocarbon degraders, this latest study identified the mechanisms the bacteria used to degrade oil and the relationship of these organisms involved in the spill to previously characterized hydrocarbon - degrading organisms.

The molecular mechanisms involved in the development of cancer have been uncovered by extensive research over the past 30 years, culminating in The Cancer Genome Atlas, a National Institutes of Health project that identified and characterized many genetic mutations that fuel cancer.

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

«While this research focused on flu infections, the mechanism we identified has implications for regulating many genes involved in anti-viral activity,» Thomas said.

While the long - term goal of the team is to understand the function of calcitriol in inflammatory diseases, identifying the kidney - specific enhancer region of the genome is already yielding insights into the mechanisms involved in bone disorders.

The researchers also identified the molecular mechanisms — particularly the role of signals from calcium ions — involved in this effect.

Using a series of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) studies, Park plans to go beyond naming the brain region where magnitude processing takes place to identify the anatomy and function of neural pathways involved in magnitude processing and reveal neural mechanisms that support mathematical thinking.

gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified

For the first time, through the use of human embryonic stem cells (hES) sourced from pre-implantation diagnosis, researchers from Inserm's Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrophy.

Our lab is interested in identifying the cellular and molecular mechanisms involved in the organization and maintenance of the synapse with a specific focus on the control of neurotransmitter receptor expression and localization.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

Klemke, Wang, and their colleagues are involved in research on aspects of the basic biology behind metastasis — trying to identify the signal transduction mechanisms that lead to the spread of breast cancer cells.

Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P - glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity.

«It comes as no surprise to me that the members of ASHG have selected Dr. Nussbaum as their President - Elect,» said NHGRI Director Francis S. Collins, M.D., Ph.D. «Bob is a prominent leader in the field of human genetics and has made considerable contributions to identifying the genetic abnormalities and destructive mechanisms involved in Parkinson's disease and Lowe's Syndrome.

Researchers have identified a host of factors involved in epigenetic control of gene expression and development, but many of the precise mechanisms underlying this type of regulation remain unclear.

«Now that we've identified a new principle for how the interneurons can control plasticity, our study is a first step in better understanding the mechanisms involved in other brain regions as well,» said Kreitzer.

She is also involved in identifying the mechanism of action of anti-tubercular compounds.

Researchers at the Center for Vascular Research, within the Institute for Basic Science (IBS), have identified a new mechanism involved in the development and progression of glaucoma, and found a potential therapeutic option...

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Despite this generally well - accepted idea for how high eye pressure may affect RGC axons, scientists still do not understand the injury mechanisms involved in sufficient detail to begin identifying potential therapeutic targets.

Our strategy is to identify basic mechanisms of proteins involved in metabolism and DNA repair to gain better understanding in disease and also develop small molecule inhibitors to selectively targeting these proteins as potential therapeutics.

Cambridge, Mass. — June 16, 2014 — A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS), have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

Researchers have already identified at least one mechanism of action involved with this immune system support.

Fortier Laboratory Dr. Lisa Fortier's laboratory investigates the underlying cellular and molecular mechanisms involved in the development of arthritis with the goal of identifying finding new ways to treat and prevention arthritis.

The claim «calling it deterministic chaos identifies the underlying mechanism» is false: more is involved in identifying a system than merely classifying it broadly and naming it.

Scientists have identified several mechanisms that may be involved.

Building upon the technical / substantive distinction, the Committee avers that Parliament should identify for more detailed scrutiny those statutory instruments that involve matters of significant policy interest or principle and should develop mechanisms to ensure meaningful scrutiny for these measures.

Further research is needed to identify the relative benefits in different population groups, its influence on outcomes such as mother - infant interaction, and the physiological mechanisms involved.