On the scientific agenda are
identifying molecular markers for resistance, which would simplify testing; accelerating the development of alternative drugs; and studying the effectiveness of mass screening and treatment to eliminate malaria in the areas where resistance occurs.
They also mined public databases (GNCPro, TiGER, Human Protein Atlas) to
identify molecular markers of the hindgut in the adult colon.
To address the pressing question of
identifying molecular markers, TRAC has partnered with the MRC Centre for Genomics and Global Health to conduct large - scale genomic analyses to identify mutations associated with ART - R.
One important benefit of this genetic approach is that, even without knowing the precise genetic causes of drug resistance, researchers are able to quickly identify resistant strains — an important step towards
identifying molecular markers to enable effective worldwide surveillance.
Last year saw publications in Nature Genetics by Miotto and colleagues about multiple strains of artemisinin - resistant parasites in Cambodia, and in Nature by Dr. Frédéric Ariey and colleagues from Institut Pasteur
identifying a molecular marker of artemisinin resistance.
Not exact matches
Several studies have used cell - surface
markers — proteins found on the outer membranes of tumor cells — to
identify glioblastoma stem cells; but the specific
markers used have been controversial and can not reflect
molecular processes going on within tumor cells.
They might also diagnose health conditions by
identifying proton - scale differences in
molecular mass that are
markers of disease.
The collaborative research team also found a
molecular marker that would help
identify patients most likely to benefit from cabazitaxel treatment.
They found that women were five times as likely to develop cancer if they had a higher percentage of Ki67, a
molecular marker that
identifies proliferating cells, in the cells that line the mammary ducts and milk - producing lobules.
Another student who was using phage - display technology to
identify new
molecular markers in ovarian cancer attended a clinic in gynecologic oncology once a week throughout her dissertation research.
Similar experiments could
identify new
markers of diseased tissue or new targets for targeted
molecular therapies.
Most simply, once these genes, or bits of DNA tied to the genes (known as
markers), have been
identified,
molecular breeders can quickly target offspring inheriting the genes for further development, cutting breeding time and improving the crop's «genetic gain,» the generational improvements made to a crop, like increased height, by human selection.
«
Molecular marker from pancreatic «juices» helps
identify pancreatic cancer.»
To develop a model for generating the human colon, scientists first
identified SATB2 (special AT - rich sequence - binding protein 2) as a definitive
molecular marker for hindgut in frogs, mice and in humans.
«Initially, the cell
identifies all potential replication origins with a
molecular marker.
Molecular markers for retinal ganglion, amacrine, bipolar, horizontal, Müller glia, and rod and cone photoreceptor cells (Table S3)
identified these cell types (Figures 5B, 5D — 5N, and S2, S3, S4, S5, S6).
This means that samples can be taken before the clinical debut of a disease, to
identify markers of value for early diagnosis, improving the scope for curative treatment,» says Ulf Landegren, Professor of
Molecular Medicine at Uppsala University and member of SciLifeLab Faculty.
Therefore, mining associated
molecular markers via association analysis might be a more powerful approach for
identifying causative variation.
With multiyear field studies, Xue
identified plant traits related to drought tolerance, which can be used by breeders to develop drought - tolerant wheat cultivars and geneticists to screen
molecular markers and speed the breeding process.
Molecular markers that point to the earliest steps in the development of lung cancer are
identified by Cancer Center scientists.
Six Xa genes have been tagged with
molecular markers and used to help
identify new resistant lines, resulting in the release of resistant varieties in several countries.
In recent years, many labs have dedicated enormous resources to
identifying new
molecular cancer
markers through «unbiased» direct profiling of human cancers using DNA microarray approaches.
«It is certainly exciting to see this idea of using
molecular markers to
identify signatures of different breeds — which had its origins in basic evolutionary genetics — make it all the way to a commercial product that has the potential to provide useful information to and satisfy the curiosity of millions of dog owners,» he said.
Whole genome association analysis studies that utilize single nucleotide polymorphism (SNP)
markers have been used to
identify the
molecular causes of various traits and conditions including genetic mutations within breeds that cause coat color variations [15], hairlessness [25] and defects in spinal development [26].