Zuo and colleagues
identified multiple compounds that protected cochlear cells from cisplatin, several of which are already approved to treat other conditions.
Not exact matches
«The
compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of
multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.
Quantitative proteomics can also be applied to
identify major candidates of proteins targets and mechanism of action by specifically designed experiments using
multiple drug /
compounds in addition to that / those of interest and probing drug /
compound - specific proteome responses to a treatment.
Multiple examples of the critical evaluation of data from new target screening to
identify novel
compounds for progression into the portfolio.