Sentences with phrase «identified signaling pathways»

In addition, we have identified signaling pathways that are activated as part of the integrated stress response in response to soluble amyloid - beta and in AD model mice.

«And this model not only shows us the most important factors that contribute to the onset of anorexia, it's also helping us to identify signaling pathways in the brain that ultimately drive this potentially fatal eating disorder.»

At the University Children's Hospital Zurich, researchers from the University of Zurich have identified a signaling pathway in liver cells that may contribute to the development of steatosis.

We are in the middle to identifying the signalling pathways required for formation of these stress assemblies as well as their composition.

A team of scientists led by Dr. Masanobu Komatsu of Sanford Burnham Prebys Medical Discovery Institute has identified a signaling pathway that is essential for angiogenesis.

Our goal is to identify signaling pathways which control or coordinate these different phenotypic transitions and to evaluate how these pathways can be influenced by the cellular environment, altered in pathological contexts or serve as therapeutic targets.

First, they used single - cell RNA sequencing to identify the signaling pathways critical for arterial endothelial cell differentiation.

Not exact matches

The Serhan lab, which focuses on identifying and elucidating the structures of bioactive molecules, has made critical discoveries over the last two decades that have illuminated the biochemical signaling pathways that resolve and control inflammation and pain associated with disease and injury recovery.

«Transcriptomics identifies genes, signaling pathways that may regulate neurodegeneration.»

«We then conducted a series of supplementary experiments to identify a probable signal pathway, from the occurrence of the genetic risk variant to clinical symptoms in the form of psychosis and cognitive impairment,» says Professor Landén.

Aside from helping to better design PD - 1 blockade treatments, Wherry's findings have also helped to identify potential biomarkers in the PD - 1 signaling pathway.

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

Evidence of endocrine, inflammatory and neurotransmitter signaling pathway disruption was also identified in the placentas.

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins.

«We have identified two components of the knee joint that control bone growth, at least following injury, and we've shown that signals from these components influence distinct growth plate signaling pathways and lead to reduced bone growth,» concludes Alexandra Joyner, PhD, senior author and Developmental Biologist at Sloan Kettering.

Yale researchers identified a specific cell - signaling pathway that is dependent on DNMT3B.

The team also identified genes that had not been previously linked to ASD, but are heavily involved in numerous protein interactions and signaling pathways.

Integrins have roles in a wide range of biochemical signaling pathways, but Parker's team identified one particular pathway that seems to play a role in injury to axons.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

In addition to NANCI, the team identified another lncRNA, which they named LL34, that regulates retinoic acid signaling, another important pathway for early lung development.

To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.

The CUMC team is currently using the new mouse model to study signaling pathways in the brain that drive anorexic behavior, with the ultimate goal of identifying therapeutic targets.

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy - induced neuropathy and HIV.

Using a bioinformatics approach, we have identified the relevant signalling pathways that make dense breast tissue more favourable for tumour formation.

The team identified a critical pathway of molecular signals which throw a lifeline to cancer cells, enabling them to survive even though they contain vast DNA errors which would usually trigger cell death.

«We have already observed that gene egr - 4 is regulated by the epidermal growth factor receptor (EGFR) signaling pathway, so it will enable to identify also the factors that activate this pathway during anterior regeneration.

They and additional co-authors at the MGH Cancer Center, the University of North Carolina, Vanderbilt University and Novartis, identified HER3 — part of the same signaling pathway that includes HER2 — as a possible contributor to anti-HER2 / PI3K resistance in breast cancer brain metastases.

Study authors then further refined the process, identifying additional molecular signaling pathways that drive formation of critical stomach cell types of the fundus.

However, her research group has not yet identified how to make stem cells yield entirely dI1 or entirely dI3 cells — perhaps because another signaling pathway is involved, she said.

«Our study identified four previously unknown phosphorylation sites in a LINK - A regulated signaling pathway,» said Lin.

In addition, it was the first time that a specific sugar chain structure that is part of the extracellular matrix in plants, has been identified as a bioactive species that functions in the signaling pathway between cells.

«But we have to further study the functions of this histone, identify the other proteins with which it is associated, and determine the enzymes that modify it and why and the cell signalling pathways involved,» explain the scientists.

The elucidation of the structure and function of this complex serves as a crucial step in the ongoing effort to identify clinically important drugs with which this important signaling pathway can be targeted.

Use of exon - based transcriptome profiling to identify novel signaling pathways and survival - associated genes in diffuse large B - cell lymphoma.

«Analysis of metastatic prostate cancers suggests treatment options: Study maps out abnormal signaling pathways in prostate cancer cells and provides computational approaches to identify individualized targets for therapy.»

In recent decades, scientists have identified genes, enzymes, metabolic pathways and signaling molecules that control those activities.

Moreover, large - scale screens in the C. elegans DMD model allowed identifying genetic and pharmacologic suppressors of dystrophin - dependent muscle degeneration; some of them positively impact mitochondrial functions or structure under stress conditions, or are involved in signaling pathways linked to mitochondria, and others are associated to proteostasis pathways such as autophagy, proteasome and Unfolded Protein Response (UPR).

With collaborators in the biology department, Dr. Weiss applied these ultrasensitive techniques to investigate the Hedgehog signaling pathway — a critical mechanism that helps give rise to the spatial patterning in developing embryos, but has also been identified as a key culprit in up to 25 % of cancer deaths.

Numerous studies have identified links between BR synthesis, sensing, and signaling with other hormone and light pathways in Arabidopsis; e.g., some of the first BR mutants were isolated in screens for light - dependent hypocotyl elongation (Clouse et al., 1996; Li et al., 1996; Neff et al., 1999; Luccioni et al., 2002).

The research described in this essay focused on understanding this pathway by identifying protein factors that form a lysosome - based signaling platform that positively and negatively regulates the function of the Rags.

Furthermore, the researchers identified biomarkers unique to the R - NSC type, as well as signaling pathways required for the maintenance of the R - NSC type.

The Wnt and TGF - β signaling pathways were identified in the gene expression analysis as being up - regulated during the day (Fig. 4).

Current projects in the laboratory include: 1) functional screens of ubiquitin ligases to identify novel cancer drug targets; 2) defining the molecular regulation of breast cancer metastasis to the brain; and 3) understanding signaling pathways that influence the response of cancer cells to chemotherapy.

Phosphotransfer - mediated signaling pathways, involved in signal transduction, have been identified in Pseudomonas as the two - component GacS / GacA global regulatory system (39).

We have identified several molecular targets such as Bcl - xL, Bcl - 2, and survivin, along with upstream signaling intermediates such as PI -3-kinase, Akt, and the canonical and non-canonical NF - κB pathways that control the activities of OX40.

The researchers also identified new links between aggressive meningioma proliferation and activation of an intercellular signaling pathway called Wnt — which typically plays a role during embryonic development and tissue formation.

In the cytoplasm, lethal toxin is a zinc metalloprotease that cleaves a number of identified proteins, including members of mitogen - activated protein kinase (MAPK) signaling pathways [33] and the inflammasome - activating sensor NLRP1B [34].

Our data implicate p38 and MAPK in IL -23-mediated signaling in ILC3s, identifying a new pathway to target in the regulation of ILC3 function.

In particular, research with the roundworm C. elegans, aided by its short lifespan and easily manipulated genetics, has identified a number of pathways that regulate aging, such as insulin / insulin - like signaling, dietary restriction, heat shock resistance, and reproductive and sensory signaling pathways.