Sentences with phrase «identified therapeutic potential»
In a new study at the University of Edinburgh, researchers have identified therapeutic potential for a protective chemical, called human beta - defensin 2 (hBD2), which is typically missing in eczema patients.
https://www.immunology.org/ Not exact matches
Turmeric contains curcumin, identified as a primary active ingredient, which reaches over 150 potential therapeutic activities, including antioxidant, anti-inflammatory and anti-cancer properties.
Researchers hope the organoids will be better than lab animals or cells growing in culture at revealing how the human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.
«By identifying key molecular drivers within these networks, we have been able to determine potential therapeutic targets that could help us to develop the first pharmacological therapy for CAVD.»
The study also reinforces the potential value of brain scans for identifying and understanding schizophrenia in individual patients, for finding promising new therapeutic approaches, and for helping clinicians track a patient's progress during therapy.
«Several lead molecules for prospective clinical use have been identified through our collaboration with Dr. Kenneth Jacobson at the National Institutes of Health and we are very excited about the potential for translational therapeutic impact,» Salvemini said.
It has the potential to identify novel, rare mutations that are «actionable» therapeutic targets,» Chinnaiyan added.
«New model for hepatitis B helps identify potential new therapeutic approach.»
UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer.
«We only used tungsten in «proof - of - concept» experiments to identify a potential molecular target, and we are still far from turning this basic discovery into a therapeutic treatment in patients,» Dr. Winter said.
In addition to uncovering compounds with therapeutic potential for Alzheimer's disease, this research presents a new approach for identifying proteins that bind to amyloid fibrils — an approach that could have broad applications for treating many diseases.
«We have identified a pathway in microglia that may be targeted to ultimately slow disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.»
«We wanted to identify some potential therapeutic targets that are common not just to one but to multiple forms of retinitis pigmentosa at late - stage disease, when it is more likely to be clinically diagnosed in a patient population.»
A comprehensive DNA sequencing of pancreatic cancer cases revealed not only a plethora of damaged genes, but potential diagnostic biomarkers that could help identify those with longer or shorter survival, and provide opportunity for new therapeutic interventions.
Therefore identifying the essential, tissue - specific effectors of Hh has the potential to lead to the identification of more specific therapeutic targets.
A new study in American Journal of Physiology — Heart and Circulatory Physiology identifies the involvement of a protective response pathway, the heme oxygenase system, that has potential as a new therapeutic strategy for cardiovascular diseases.
Dr Tew, said: «Our research has the potential to identify different sub-groups of patients, including those in the early stages of OA, that could benefit from therapeutic interventions.
«New color blindness cause identified: Finding suggests potential therapeutic targets.»
The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still - incurable neurodegenerative disease.
«Potential therapeutic target for wound - healing, cancer identified.»
The overall goal of the TGen study was to look at genomic and epigenomic events to understand the causes of breast cancer brain metastatic lesions, and identify potential new therapeutic targets.
Professor Andrew Lotery, who led the Southampton contribution, hopes the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.
«Given the therapeutic potential of the nSMase target, we're now working closely with Drs. Barbara Slusher, Camilo Rojas, Ajit Thomas and colleagues at the Johns Hopkins Drug Discovery facility to identify potent inhibitors of the nSMase enzyme which can be developed for clinical use,» says Haughey.
«This animal study is the first to identify a treatment that slows the disease once symptoms have already appeared, a significant finding that offers insight into the disease mechanism and important therapeutic potential,» notes study co-author Jeffrey Rothstein of Johns Hopkins University.
While the researchers can not yet point to a potential therapeutic application of their findings, identifying genetic changes that underlie MND is the first step in finding ways to manipulate these changes using gene therapy.
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies potential new therapeutic avenues for patients with Alagille syndrome.
Currently he and his undergraduate and graduate students are modifying fatty acids in yeast with the ultimate goal of identifying pathways to natural products with therapeutic and economic potential.
«Through the dedicated work of translational scientists, we are beginning to uncover the mechanisms that unleash the symptoms of celiac disease and identify potential therapeutic targets.»
Next we use such assays to identify LEAD chemical compound (s) with therapeutic potential for HD or to validate drug or gene - based therapeutic approaches developed by our collaborators (Pr.
More specifically, I identify and examine novel mechanisms governing these factors as potential therapeutic interventions.
The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.
Previous investigations had identified hUPF1 as a potential therapeutic target for ALS, but it was unclear how this protein prevented cell death.
Functional abnormalities will be identified and potential therapeutic compounds will be tested for their ability to revert these dysfunctions.
These models would be ideal platforms for identifying new genetic treatments and validating potential therapeutic options.
They hope to identify a potential therapeutic target for Zika virus.
Perform phenotypic profiling in primary human cells to identify and characterize candidate genes with therapeutic potential,
Gladstone scientists identify inflammatory pathways as a potential therapeutic target for frontotemporal dementia
PrediXcan has the potential to identify gene targets for therapeutic applications faster and with greater accuracy than traditional methods.
This project has the potential to uncover clinically relevant mechanisms of cellular senescence in fibrosing ILDs and identify new therapeutic targets
Researchers at the Center for Vascular Research, within the Institute for Basic Science (IBS), have identified a new mechanism involved in the development and progression of glaucoma, and found a potential therapeutic option...
If these transporters are identified, a similar approach can be used to establish the therapeutic potential of such transporters in other cancer subtypes as well.
However, a great deal of basic research is still required to understand the molecular bases of rare diseases and identify potential therapeutic targets.
The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.
Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5
Despite this generally well - accepted idea for how high eye pressure may affect RGC axons, scientists still do not understand the injury mechanisms involved in sufficient detail to begin identifying potential therapeutic targets.
Several small molecules modulating autophagy have been identified that have potential therapeutic application in diverse human diseases, including neurodegeneration.
By building this scientific knowledge into the variability of CSAs, we are better able to identify potential therapeutic options for each sub-type of the disease.
Together, these data define METTL3 as a regulator of a chromatin - based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia.
Temporal specimens collected and tested during the course of treatment identify the loss or elimination of driver mutations as well as emergence or re-emergence of new clones and new potential therapeutic targets.
Liaison between clinical and basic sciences can be utilized to achieve this, including maximizing the potential of genomic data to tailor individualized treatments, collecting natural history information to identify disorder - specific management requirements, developing new therapeutic approaches through improved knowledge of molecular pathways and protein network interactions, and testing potential new drugs via well - conducted clinical trials.