Not exact matches
We also
sequenced 35 samples from suspected EVD cases that tested negative for EBOV; genomic analysis
identified other known pathogens, including Lassa
virus, HIV - 1, enterovirus A, and malaria parasites (fig.
However, they
identified genetic
sequences matching
viruses that infect dogs, chickens, and pigs, suggesting the possibility that some of the
viruses had crossed over from other species.
While sifting through metagenomic
sequence datasets for a U.S. Department of Energy Joint Genome Institute (JGI) Community Science Program project, researchers
identified genome
sequences typically found in giant
viruses.
Lipkin then used a rapid genome -
sequencing technique to
identify RNA from a variety of bacteria, fungi, and
viruses.
The panel
identified human papilloma
virus (HPV)
sequences undetected by conventional laboratory tests as well as new unreported HPV mutations.
Sequencing the genome allowed researchers to
identify the gene for lysin, an enzyme that the
virus uses to kill bacterial cells, that has potential use as an antibiotic or disinfecting agent.
Within months, researchers had
identified the
virus,
sequenced its genome, and stemmed its spread.
Genetic
sequencing identified the RNA genome as a member of the insect - infecting Cripavirus genus, but the DNA viral genome was more mysterious: It was unlike any
sequenced present - day
viruses, but distantly related to plant - infecting geminiviruses.
Again they
sequenced the
viruses they found in the various mosquito tissues, and they
identified two new mutants, both with mutations in the same lock - picking coat protein as the original Reunion mutant, results they published last year in Cell Host and Microbe.
Analysis of the Nematostella vectensis (an Anthozoan) genome and the Hydra magnipapillata (a Medusozoan) EST library
identified several herpes - like viral genes and mRNAs within the draft
sequences supporting a hypothesis that herpes - like
viruses are found in all Cnidarians and likely have co-evolved with the metazoans.
The team's first significant breakthrough was in fully
sequencing the
virus genome and
identifying its structure.
While there are techniques to
identify known
viruses, such as high throughput
sequencing or high density microarrays,
identifying truly novel virions could pose a problem, the authors write.
His contributions include the first use of genetic methods to
identify an infectious agent; implication of West Nile
virus as the cause of the encephalitis in North America in 1999; invention of MassTag PCR and the first panmicrobial microarray; first use of deep
sequencing in pathogen discovery; and molecular characterization of more than 600
viruses.
In 2006,
sequences corresponding to a novel gammaretrovirus named xenotropic murine leukemia
virus - related
virus (XMRV) were
identified in tissue from prostate cancer patients following radical prostatectomy [1].