Sentences with phrase «identifies gene families»

«Scientists sequence genomes of microscopic worms beneficial to agriculture: Study identifies gene families in five nematodes that are likely to be involved in parasitism.»

Not exact matches

If you have a strong family history of breast cancer or other cancers, your doctor may recommend a blood test to help identify specific mutations in BRCA or other genes that are being passed through your family.

The gene plaguing her family was identified by geneticists Mark Skolnick and Mary - Claire King in 1994 after an intense search.

Using a genome - wide genetic screen, Dr. Gelman and colleagues identified a previously unknown metastasis suppressor — the FOXO4 protein, which belongs to a family of genes that are produced by all human cells.

A team led by Margaret Pericak - Vance of Duke University, Jonathan Haines of Vanderbilt University in Nashville, Tennessee, and Allen Roses — a former Duke researcher now in charge of genetics research at the Glaxo Wellcome Company in Research Triangle Park, North Carolina — scanned the DNA of members of 16 large families with a high rate of Alzheimer's, looking at 280 genetic markers that might help identify candidate genes.

«Mutations responsible for cleft palate and related birth defects identified: Study of Amish and Saudi Arabian families finds mutations in HYAL2 gene that impact development.»

One end of the boy's swapped DNA lodged itself in the same region that the Oxford team had identified in the West London family, right in the middle of the FOXP2 gene.

Scientists have identified the first gene that may contribute to autism, a type of mental retardation long thought to run in families.

She identified a region on chromosome 8 where the affected family members had distinctly different genes.

They identified and isolated a gene family with GNA1 function, which was confirmed by enzyme activity assays in vitro and by its capacity to restore growth in yeasts lacking GNA1.

The ideal way to identify a gene network in humans would require an impossible experiment: Take two families, each with dozens of identical twins, and have the families interbreed, combining the same sets of genes together over and over again.

Both offspring in this family have two recessive disorders: Miller syndrome, for which the gene was concurrently identified, and primary ciliary dyskinesia, for which causative genes have been previously identified.

Bierut and her colleagues analyzed data gathered through the Collaborative Study on the Genetics of Alcoholism (COGA), a large, multi-center, family study designed to identify genes that contribute to AUDs.

Nevertheless, he believes that the new research may eventually lead to strategies for preventing MS. «In cases where multiple sclerosis runs in families, one could identify children who have inherited high - risk genes, and give them preventive vaccines,» he says.

After sequencing the gene, the researchers identified a mutation that was present in all affected family members.

Researchers studying two generations of a family affected by pediatric acute lymphoblastic leukemia (ALL) have identified an inherited variation in the ETV6 gene that is associated with an increased risk of developing the disease.

It is particularly useful when clinicians want to identify an illness or gene mutation involving a single patient or the patient and two or three other family members, which is the most common clinical situation for undiagnosed diseases.

Using methods for analyzing gene expression in mice, they identified several members of the «BMP» family of proteins from among more than 20,000 possible candidates.

In a similar case with a 12 - year - old whose exome was sequenced without any family data, Phevor built on the analysis of VAAST to identify a gene mutation causing the illness, another autoimmune syndrome.

The researchers then identified children, among other families, who carried the single candidate gene.

With the help of systematic re-sequencing of all X-linked genes, the responsible genetic defect can be identified in around 60 percent of families with X-linked intellectual disability.

The researchers» next step is to use the genomic data they collected from the families — including full genome sequences and gene expression data — to begin identifying the specific genes that contribute to risk for bipolar disorder.

A systematic search of the nonrecombining region of the human Y chromosome (NRY) identified 12 novel genes or families, 10 with full - length complementary DNA sequences.

Ever since the gene for CF was identified in 1989, much debate has centred on whether the general public should be screened to detect carriers, or whether screening should be restricted to affected families.

Through genetic analysis of a family with a history of thoracic aortic aneurysm and dissection (TAAD), investigators at Brigham and Women's Hospital and Washington University School of Medicine in St. Louis have identified mutations in the LOX gene, a gene associated with the integrity of the arterial wall, in human subjects for the first time.

In addition to the 1,274 genes that take part in coding proteins, they also identified 375 novel noncoding gene families on the bovine Y chromosome, which are predominantly expressed in different stages of the testis.

Previously, genetic counselors tested a small number of genes sequentially based on family profile and tumor analysis until the culprit was identified.

Strong family disease history suggests a hereditary contribution and future research will try to identify the gene mutations responsible.

Such families can be studied by modern molecular genetic methods in ways that allow the causative gene to be identified.

A year ago we started thinking, why don't we select a single family with an interesting disease and see whether studying a smaller group of related individuals makes it possible to identify the genes involved in that disease.

Mary - Claire King, 68, of the University of Washington, Seattle, won the Lasker special achievement award for her discovery of the BRCA1 breast cancer risk gene in 1990 and for developing DNA analytic techniques for identifying members of a family.

They also identify factors that may be involved in duck host immune response to avian virus infection, including the avian and mammalian - defensin gene families.

Although it shows no sign of the whole - genome triplication identified in Solanaceae species such as tomato, the genome includes several species - specific gene family expansions, among them N - methyltransferases (NMTs) involved in caffeine production, defense - related genes, and alkaloid and flavonoid enzymes involved in secondary compound synthesis.

The two families had distinct facial dysmorphic features that led Karaca to identify the gene in three additional families with very similar features.

Using whole exome sequencing (a next generation test to analyze the exons or coding regions of thousands of genes simultaneously) conducted at the Baylor College of Medicine Human Genome Sequencing Center, the researchers identified CLP1 mutations in two unrelated families with the disorder.

Focusing their search on receptors not known to respond to any odor, the researchers identified one family of genes that appeared to be expressed in olfactory neurons but not in other tissues.

This gene family was originally identified as important for balance: mice with mutations in otopetrin 1 (Otop1) are called tilted (tlt) because they can not right themselves.

Dubbed the «speech gene,» FOXP2 was first identified in 2001 when scientists found a mutated version in a family with severe speech problems.

Aung Ko Win, M.B.B.S., Ph.D., M.P.H., of the University of Melbourne, Victoria, Australia, and colleagues conducted a study that included 1,128 women with an MMR gene mutation identified from the Colon Cancer Family Registry.

This is in contrast to the well - characterized VRC01 - like family of CD4 - binding site antibodies identified in multiple HIV - positive donors, which share both a heavy chain V gene precursor and unusual features at a DNA sequence level which could allow sequencing - based identification of other similar antibodies in distinct patients [53].

The advent of microarray technology, with its capacity to monitor the expression of thousands of genes simultaneously, has provided a novel opportunity to identify individual genes, groups of genes, and related «gene families» associated with a given biologic process.

From a more global perspective, 22 gene families, of the over 200 identified, were found to be significantly altered by hypoxia.

Three separate ADAR gene family members (ADAR1 - 3) have been identified in humans and rodents.

We identified and characterized a novel member of the forkhead gene family that is essential for proper regulation of satellite cells.

A relatively new technology called exome sequencing has identified a few families with novel mutations in their HD genes.

In addition to identifying new genes, researchers hope to find genetic markers that might influence how a known genetic syndrome presents within a particular family.

According to their study, published in the current issue of the journal Cell, these genes — from the Wnt family — interact with another set of previously identified growth factors to induce limb formation in chick embryos.

The illness runs in families, and is known to have a strong genetic component, though efforts to identify the specific gene or genes that predispose a person to schizophrenia have so far been inconclusive.

Poster Presentations Allison Schreiber — «CHD7 Variants in Two Families with Evidence of Parent - to - Child Transmission of CHARGE Syndrome» Patty Arscott — «Genetic Counseling Dilemma: Multiple Gene Variants Identified Through Genetic Testing for Hypertrophic Cardiomyopathy» Christina Rigelsky — «Clinical Features of Three Patients with Vascular Ehlers - Danlos Syndrome as the Result of COL3A1 Functional Haploinsufficiency with Stable mRNA but Unstable Protein» Rebecca Cook — «Assessing the Utility of Four Educational Videos Concerning Alpha - 1 Antitrypsin Deficiency» and «Guidelines for Advocacy Organizations Considering Establishing a Registry or Biobank» Educational Breakout Session Presentations Meg Doerr — «Using Information Technology to Facilitate the Cancer Genetic Counseling Process»

But now scientists at The Salk Institute have identified a family of genes that plays a critical role in triggering the growth of limbs.