Sentences with phrase «identifies gene sets»

The method identifies gene sets that show evidence for positive selection in comparison with matched controls, and thus highlights genes for further functional studies.

The scientists were thus for the first time able to identify gene sets responsible for steering specific memory processes.

«And this approach could be used in conjunction with high - throughput screening techniques to identify gene sets associated with problems such as multidrug resistance or benefits, like those related to probiotics.»

Not exact matches

To generate a rich source of potential vaccine and drug target candidates, the team identified a set of genes that are more active in certain stages of the parasite life cycle and within the parasite's gut.

«The advantage of being able to adjust a set of genes identified as key autism risk factors may explain the strong and long - lasting efficacy of this therapeutic agent for autism.»

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

Next, Anderson and his colleagues used a set of genetic tools to identify exactly which neurons were responsible for the effect on aggression and to see if the gene that encodes for Tk also controls aggressive behavior by acting in that cell.

Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

The full data set, with genes identified, is publicly available from EMBL - EBI's Ensembl database.

As she set out to design her research, she noticed that many genes being identified were linked to high BMI, which simply compares someone's weight with their height.

The study identifies a wide set of genes — previously associated with complex structures in higher animals — which were supposedly absent in sponges.

In a series of experiments sparked by fruit flies that couldn't sleep, Johns Hopkins researchers say they have identified a mutant gene — dubbed «Wide Awake» — that sabotages how the biological clock sets the timing for sleep.

Scientists led by cancer biologist Wen - Hwa Lee of the University of California, Irvine, set out to identify genes regulated by BRCA1.

Johns Hopkins researchers say they have identified a set of genes that appear to predict which tumors can evade detection by the body's immune system, a step that may enable them to eventually target only the patients most likely to respond best to a new class of treatment.

Researchers have identified a new set of genes that may be responsible for the two most common and disabling neurological conditions, stroke and dementia.

In a study exploring the molecules controlling osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclasts.

«By identifying the full set of genes in each of these two cell types, we provide detailed information that taste scientists can use to help understand how these cells work, both when healthy and also when affected by damage or disease.»

Importantly, the team identified a set of psoriasis - related genes in keratinocytes that are regulated by IL - 17A.

The ideal way to identify a gene network in humans would require an impossible experiment: Take two families, each with dozens of identical twins, and have the families interbreed, combining the same sets of genes together over and over again.

White and her colleagues set out to identify how FoxP2 affects thousands of other genes in zebra finches before and after the critical period for learning closes.

Many of the bacteria that were identified were similar to oil - degrading bacteria found on the ocean surface but had considerably streamlined sets of genes for oil degradation.

Using sophisticated genetic sequencing technology, King and Yin identified a common set of genes that are controlled by a shared network of genetic regulators known as microRNAs.

In their research, Pugh and Venters set out to identify the precise location of the beginnings of transcription — the first step in the expression of genes into proteins.

This same feature, tumor heterogeneity, may reduce the ability to identify critical gene expression changes when comparing mean gene expression in adjacent tumor and normal tissues, as tumors of the same type may have different sets of genes differentially expressed.

A small set of maternal genes have been identified that are required for these activities.

From these efforts, we identified a high - quality orthologous gene set across avian species, consisting of exons from 8251 syntenic protein - coding genes (~ 40 % of the proteome), introns from 2516 of these genes, and a nonoverlapping set of 3769 ultraconserved elements (UCEs) with ~ 1000 bp of flanking sequences.

From the genome wide scan, a set of gene loci correspond to thermostatic regulation has been identified.

Sixty - six classifier genes were identified that distinguished infants with and without bacterial infections in the test set.

18 By studying these cichlids, scientists in Tennessee and Georgia have identified the master set of genes that regulate the construction of all teeth in the animal kingdom.

In this study, the parallels between the species were established because almost all of the sets of genes the team identified were associated with either queen or worker traits.

Prior exome studies of intellectual disability and schizophrenia, the authors note, have turned up sets of genes significantly overlapping those identified in the new ASD study.

To start, the scientists examined previous experiments and identified several transcription factors — managerial proteins that switch on the activity of large sets of genes — that seemed crucial to the ability of immature neurons to develop into adult sensory neurons.

After identifying the set of predictive genes, the team used another collection of 82 samples to confirm that the crystal ball accurately predicted a strong flu response.

So Ronald and her team set out to identify the specific genes that allow some plants to weather the storm.

The Finnish researchers had used a set of «gene wrenches» called RNAi molecules, to turn off genes of interest, and with these additional experiments the researchers identified tracks leading to a nuclear protein and gene controller protein called SRF.

We have long known that autism itself is genetic, but by combining these different data sets (brain imaging and genetics) we can now identify more precisely which genes are linked to how the autistic brain may differ.

They hope to identify the complete set of DNA binding sites and corresponding target genes for the regulons in embryonic stem cells and a subset of the cells they differentiate into.

Utilizing the invasive breast cancer data set of 962 cases in The Cancer Genome Atlas, all breast cancers with alterations in the CDH1 gene (that gives instructions to make a protein that causes cancer cells to stick to one another and defines lobular breast cancers) were identified.

Here, we identified genes controlling greening directly downstream of the GATAs by integrating data from RNA - sequencing and microarray data sets.

Next up: researchers are set examine the 2,000 strongest signals to see if they can identify a «gene network» that may be behind type 1 diabetes.

Because of the usefulness of this information, we set ourselves the goals of constructing a zebrafish gene set based on RNA - Seq alone and then identifying the highest quality models.

The authors next took 997 tumors in the discovery set, integrated copy number and gene expression data, and performed clustering analyses to identify subgroups of tumors with distinct features and clinical outcomes.

SAM analysis was used to identify statistically significant changes in microarray data, and the bioinformatics programs GoMiner, Gene Set Enrichment Analysis (GSEA), and HiMAP were used to identify significant ontological categories and analyze the N - methyl - D - aspartate (NMDA) receptor interactome.

PHILADELPHIA (August 8, 2017)-- A significant technological advance from the Monell Center now allows scientists to identify the complete set of genes in any type of taste receptor cell.

conduct computational meta - analyses on large, aggregated cancer genome data sets to identify the long tail of infrequently mutated cancer genes, to characterise mutational signatures and to inform on the evolution of cancer cell clones.

Heart buds nudge toward one another... to form a beating heart In one study, researchers identified a set of genes needed to prompt the two buds of heart cells that form early in development to migrate toward one another to form a single beating heart.

Analysing 1612 samples from 15 locations in Southeast Asia and Africa, the researchers were able to identify 20 mutations in the kelch13 gene, a known artemisinin resistance marker, that appear to work in concert with a set of background mutations in four other genes to support artemisinin resistance.

Among other findings, SWIF (r) identified several adaptive mutations in a set of genes responsible for energy and fat storage.

Within this gene, the deCODE team identified haplotypes, or specific sets of genetic markers, that correspond both to significantly increased risk of stroke and to significantly decreased risk.

Herein, we identify 382 of the 482 M. genitalium protein - coding genes as essential, plus five sets of disrupted genes that encode proteins with potentially redundant essential functions, such as phosphate transport.