Sentences with phrase «identify t cell»

In the early 1980s, Allison was one of the first to identify the T cell receptor — the part of a T cell that binds to antigen and functions as the T cell's ignition switch.

To identify this T cell population, the researchers took biopsies at the sites of active lesions before treatment and biopsies of the same skin areas after the lesions had cleared on therapy.

But Clark and her colleagues have taken a new approach: instead of looking during the height of activity, they examined lesion sites after treatment, and identified T cell receptors of cells at these sites that were shared across psoriatic patients but not found in healthy individuals or those with other skin conditions.

Using JanusMatrix, we have identified T cell epitopes in H7N9 influenza HA protein that are highly conserved with human genome epitopes, and these epitopes possess low immunogenicity, activate natural Tregs and suppress bystander effector T cell responses in vitro.

Then, in 1995, when no one else was even thinking there would be such a thing, he identified the T cell's brakes, in the process opening up a whole new vista in cancer treatment.

Following completion of a massive epitope discovery effort (also supported by an HHS contract), current work on MTB includes development of tools to isolate MTB - specific T cells (supported by the Gates Foundation) and identifying T cell signatures that distinguish three possible infection states: cleared infection, stable latent infection, and latent infection with high risk of progression to disease (in conjunction with a large consortium led by Henry Blumberg at Emory University).

In the present NONA immune longitudinal study, we further examine the previously identified T cell immune risk phenotype (IRP), relative inflammatory activity, morbidity and 2 - year mortality in very old individuals > 90 years.

Not exact matches

Weeks later, Yee realized that he didn't have the equipment he needed to pluck out of Ziskin's blood the rare (perhaps one in 100,000) T cells that could identify the subtle peptide markers on the surface of her cancer cells and attack the disease.

This discovery led the researchers to identify a mechanism where ileal Crohn's disease appears to be induced by bile acids when T cell adaptation does not occur the way it should.

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body,...

«In fact, 85 percent of the T cell receptors classified correctly had not previously been identified,» Thomas said.

«With this algorithm we have a system to identify critical features of T cell receptors that recognize the same antigen and how they interact.

Instead they identified a third way: IL - 6 can also be displayed on the cell surface of dendritic cells and thus be directly presented to T cells.

Lu's team will extract immune cells called T cells from the blood of the enrolled patients, and then use CRISPR — Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells.

Roswell Park Cancer Institute (RPCI) researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

T cells are key actors in the body's defenses, identifying foreign or diseased cells and leading an assault on them.

But no T cell antigen receptor (TCR) had yet been identified.

But controversy arose in 1991, when a team led by pharmaceutical researcher Peter Linsley identified another protein molecule, CTLA - 4, which closely resembled CD28 and was found only on activated T cells.

Doctors diagnosed the problem as alopecia areata, a genetically determined autoimmune disease in which the body's T cells identify hair - follicle cells as foreign invaders and try to destroy them.

Several years ago, when Feske and his colleagues were at another institution, they were the first to identify ORAI1, a new calcium channel, which is essential for calcium influx and T - cell function.

Researchers are also working to develop a trial where they will reprogram CAR T cells to identify the CD19 and CD22 proteins simultaneously, enabling them to target the cancer cells from more than one angle with the initial round of T - cell immunotherapy.

Here, Patil et al. have carried out single RNA - seq and sequenced the T cell receptors (TCRs) of CD4 + T cells from human blood to identify precursors that give rise to CD4 - CTLs.

It reports that mice rendered immune to dengue show «cross-protection» from subsequent Zika infection and then identifies specific types of immune T - cells capable of defending against both viruses.

«Molecule identified that helps give resident T cells in the skin their anti-cancer punch: The molecule CD103 is key to the long - term residence of T cells in the skin and to their potent anti-tumor response against melanoma.»

The treatment, called CAR - T immunotherapy, uses genetically engineered T cells, immune system fighters usually tasked with identifying invaders in the body, such as bacteria, viruses or foreign cells.

(CD8 + T cells are programmed to identify and eliminate cancerous and infected cells.)

«Not only did we find that LIGHT expression promoted tumor regression, upon further study we also identified the specific type of T - cell — CD8 — that was responsible for shrinking the tumor,» Maker said.

«He identified a type of molecular sensor, which programmed T cells isolated from human blood with customized instructions for thwarting attack.

Professor Tobias Bopp, Professor Edgar Schmitt, and Dr. Alexander Ulges of the Institute of Immunology at the University Medical Center of Johannes Gutenberg University Mainz (JGU) have made major progress towards explaining the underlying mechanisms by identifying a previously unknown sub-population of regulatory T cells.

«Uncovering why psoriasis recurs: Study identifies population of resident T cells that may initiate psoriasis and allow skin lesions to recur after therapy ends.»

Now that they have identified the long lived, skin resident T cell population that appears to be driving recurrence, the team plans to search for new therapies that can deplete these resident T cells, potentially driving the disease into long term remission.

«Scientists identify a new population of regulatory T - cells.»

Their preliminary results identified two types of immune cells, CD4 + and CD8 + T cells, which become mobilized to attack various surface molecules on the TB bacterium.

Current efforts are focused on identifying TB - specific surface proteins that are targeted by CD4 + and CD8 + T cells and testing them in their multi-organ computational model.

Researchers led by St. Jude Children's Research Hospital have identified a genetic variation associated with influenza severity and the supply of killer T cells that help patients fight the infection.

The paper identified two barriers: a wide variation in EGFRvIII expression in patients and a resistance in the tumor microenvironment, which researchers showed became even more immunosuppressive following CAR T cell infusion.

Researchers from the University of Missouri School of Medicine have identified a molecular mechanism that operates in memory T cells that could be manipulated to produce and maintain more memory T cells in the body, a finding that could improve vaccinations and cancer immunotherapies.

Now, researchers from the University of Missouri School of Medicine have identified a molecular mechanism that operates in memory T cells that could be manipulated to produce and maintain more memory T cells in the body, a finding that could improve vaccinations and cancer immunotherapies.

Research led by scientists at the Gladstone Institutes has identified the precise chain of molecular events in the human body that drives the death of most of the immune system's CD4 T cells as an HIV infection leads to AIDS.

«This one - two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS, Dr. Greene's lab has been able to identify a potential new therapy for blocking the disease's progression and improving on current antiretroviral medications.»

Using bioinformatics tools to identify and map out specific components and regulatory interconnections, the study team found highly dynamic activities during CD8 + T cell responses: a distinct repertoire of super enhancers — groups of enhancers that interact with promoters to drive gene transcription, new groups of enhancers that jump into activity only in the memory cell stage, and extensive re-wiring of regulatory circuits from one cell stage to another.

«Our studies have investigated and identified the root cause of AIDS — how CD4 T cells die,» said Gladstone Staff Research Investigator Gilad Doitsh, PhD, who is the Nature paper's lead author, along with Nicole Galloway and Xin Geng, PhD.

«In addition, although many shared properties exist between infection and cancer, future studies identifying distinct regulatory wiring in cancer - infiltrating T cells are essential for the continued progress of cancer immunotherapy.»

The three stages of CD8 + T cell development are well known, but the current study identifies a detailed map of the regulatory circuitry, such as interactions between enhancers and promoters — genetic regulatory regions that function together in driving genes to transcribe proteins to carry out biological processes.

A key challenge of treating these cancers has been to identify a way of eliminating the abnormal T - cells whilst sparing the healthy ones that play an essential role in providing protection against infections.

Led by Ludwig Lausanne investigator Alexandre Harari and George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne, the study shows that ovarian tumors harbor highly reactive killer T cells — which kill infected and cancerous cells — and demonstrates how they can be identified and selectively grown for use in personalized, cell - based immunotherapies.

To overcome these limitations, we used two - color flow cytometry to identify and select microvascular endothelial cells from primary cultures obtained from different organs of mice whose tissues harbor a temperature - sensitive SV40 large T antigen (H - 2Kb - tsA58 mice; ImmortoMice).

Published Thursday January 21st, 2016 in the journal Cell Reports, a team from Cardiff University's Systems Immunity Research Institute identify a molecule in the body — known as L - selectin — which directs the body's killer T cells to the site of a virus.

While additional study is clearly needed, our current studies have clearly identified off - target disruption in two of the top 15 putative off - target sites: an extragenic site on chromosome 12 and in the metalloprotease ADAMTS17, which is not expressed in CD4 + T cells.

The similarities of J - Lat cells to latently infected CD4 + T cells have established the utility of this experimental system for identifying and characterizing mechanisms of HIV - 1 latency.