Sentences with phrase «identify additional genes»

This research includes identifying additional genes associated with disease incidence in order to identify potential drug targets.

Not exact matches

The researchers identified several reasons for this: The new gene constructs interfere with the plant's own gene for producing growth hormones, and the additional gene constructs were not, as intended, active solely in the kernels, but also in the leaves.

Jaenisch says that the method that identified the single point mutation in SNCA's enhancer could be used to pinpoint additional pathogenic genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

Zhu and his colleagues have begun conducting additional research to determine whether the newly identified genes respond to existing hypertension medications.

Also, future studies could identify additional longevity genes by recruiting more centenarians for analysis.

The Finnish researchers had used a set of «gene wrenches» called RNAi molecules, to turn off genes of interest, and with these additional experiments the researchers identified tracks leading to a nuclear protein and gene controller protein called SRF.

The two families had distinct facial dysmorphic features that led Karaca to identify the gene in three additional families with very similar features.

The newest study from the Autism Speaks MSSNG project — the world's largest autism genome sequencing program — identified an additional 18 gene variations that appear to increase the risk of autism.

Pandolfi and colleagues sought to identify an additional tumor suppressing gene or pathway that may work in concert with PTEN to drive metastasis.

«We're confident that applying this same approach to a lot of new data will help us discover additional genomic variations and identify specific genes that play a role in schizophrenia and other psychiatric conditions.»

Additional file 11: Expression of newly identified genes in regenerating newt tissues.

She identified that specific killing of myeloid cells represents an additional mechanism of suppression mediated by Tr1 cells, and she contributed to the definition of a new protocol for Tr1 cell induction using IL - 10 gene transfer and in the discovery of the biomarkers of Tr1 cells.

The United Kingdom - based group, led by Julie Williams, Ph.D., Cardiff University School of Medicine, Wales, found the same genes as risk factors and identified a gene variant ABCA7 as an additional gene of interest.

«But if we can add additional genes into the screening, we can refine the prediction of the disease, we can increase the accuracy, we can probably even identify higher percentages of at - risk individuals.»

Linkage analysis has been used to attempt to identify additional late - onset AD genes.

As mRNA isolation is simple and since DNA microarrays are a proven genomics reagent for monitoring differential gene expression, a genome - wide expression analysis may be the fastest and most efficient method for identifying additional candidate effectors of colony queen number.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

Gerard Schellenberg, Ph.D., University of Pennsylvania School of Medicine in Philadelphia, leads the consortium, which aims to identify the additional risk factor genes for late - onset AD.

However, the study also identified two additional genes that are associated with rheumatoid arthritis in Arabs but are not in Europeans and East Asians.

Here, we identify three additional novel mutant alleles of the SHELL gene, which encode a type II MADS - box transcription factor, and determine oil yield via control of shell fruit form phenotype in a manner similar to two previously identified mutant SHELL alleles.

This gene finding may allow scientists to identify patients with this aggressive form of the cancer and target them with additional therapies.

Finally, we identify additional immune genes based on homology to manually curated immune gene families from ImmunoDB [11].

Finding just a single additional case with a deleterious variant in the same gene and overlapping phenotype may provide sufficient evidence to identify the causative gene, but today, case data sits in isolated databases.

In an attempt to identify possible ramifications of gene drives, the National Academy of Sciences has assembled experts to assess current regulations and recommend whether additional oversight is needed.

We identified additional exons for many of the receptor genes: 866 and 68 OR genes have exons 5 ′ and 3 ′ to the coding sequence, respectively; and 163 and 79 VR genes have exons 5 ′ and 3 ′ to the coding sequence (Figure 7A — B).

She is scanning the genomes of individuals in the current study to identify regions that may contain additional gene candidates.

To identify additional alterations, the investigators looked at DNA copy number changes, or changes in gene number resulting from the deletion or amplification (multiplication) of sections of DNA in the genome.

Additional analysis identified other genes that may play important roles in lung cancer development.

Veröffentlichung Q. Fan et al., Meta - analysis of gene - environment - wide association scans accounting for education level identifies additional loci for refractive error, Nature communications 7, 11008, 6.

Since then, the Lodish lab has identified additional FATP genes, five in mice and six in humans.

In these analyses, we identify and subsequently analyze a set of 107 autosomal genes with a false discovery rate (FDR) of < 30 %; in total, this larger set of genes harbor de novo loss of function (LoF) mutations in 5 % of cases, and numerous de novo missense and inherited LoF mutations in additional cases.