Breeden, Prentice and Zhao, whose study appeared in the May 8 Proceedings of the National Academy of Sciences, compared their new algorithm to other methods used to analyze microarray experiments designed to
identify cell cycle genes in yeast.
Not exact matches
Some of the common genetic alterations
identified in the study were gains and losses in chromosome 8, as well as
cell proliferation and
cell -
cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the
genes AURKA, AURKB and FOXM1.
Srivastava and his team
identified four
genes involved in controlling the
cycle of
cell division.
«Even though we
identified 81 percent of the
genes that were already known to be
cell -
cycle regulated, we found only about a 65 percent overlap between
cell -
cycle genes identified by our method and the previous method.
Breeden anticipates using this method to
identify coordinately regulated
cell -
cycle genes and ultimately elucidating the mechanisms that control their
gene expression.