Sentences with phrase «identify cells expressing»

Immunocytochemistry identified the cells expressing stage - specific embryonic antigen (SSEA) 1, OCT - 4, and VASA proteins in the EBs.

Not exact matches

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

Research led by Ed Morrisey, PhD, professor of Medicine and Cell and Developmental Biology in the Perelman School of Medicine, University of Pennsylvania and scientific director of the Penn Institute for Regenerative Medicine, has identified hundreds of these lncRNAs, sometimes called the «genomic dark matter,» that are expressed in developing and adult lungs.

Dr. Espen Spangenburg, associate professor of kinesiology, and his laboratory team are the first to identify that the BRCA1 protein is expressed in the skeletal muscle of both mice and humans, and that it plays a key role in fat storage, insulin response and mitochondrial function in skeletal muscle cells.

The team has identified that aggressively spreading cancer cells express a protein called Myosin - 10 which drives cancer cell motility.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

Lastly, the team identified a gene, calretinin, in the hippocampal cells which was not expressed in the neocortical cells — suggesting the possibility that these cells exhibit different functional properties as well.

At Gritstone Oncology, researchers pair deep learning with multi-omic profiling to characterize a patient's cancer and identify unique antigens that aren't expressed by healthy cells.

At the Dana - Farber Cancer Institute and the Broad Institute, for instance, Todd Golub, a specialist in the genetics of cancer, had spent a decade learning how to identify malignant tumors by the pattern of protein - coding messenger RNAs expressed in their cells.

In the study, Stephen Maricich and colleagues identified a subpopulation of Atoh1 - expressing cells in hair and whisker follicles within mouse skin that exclusively give rise to Merkel cells during development and adulthood.

The researchers identified a protein, SOCS3, that is highly expressed in normal cells but undetectable in triple - negative breast cancer.

In combination with a separate technique that measures the degree to which a gene is expressed, the researchers then identified genes that were either mutated or functionally altered through expression levels in these bladder cancer cell lines.

Molecular profiling of PI cells identified the fly version of DH44 as a circadian molecule that is specifically expressed by PI neurons and required for normal rest / activity rhythms in flies.

Liman's lab used a molecular genetics technique called RNAseq to identify which genes were specifically expressed in sour taste cells and not other types of taste cells.

While additional study is clearly needed, our current studies have clearly identified off - target disruption in two of the top 15 putative off - target sites: an extragenic site on chromosome 12 and in the metalloprotease ADAMTS17, which is not expressed in CD4 + T cells.

To find out if these chemical changes do indeed take place, the researchers first identified a group of engram cells in the hippocampus that, when activated using optogenetic tools, were able to express a memory.

(H) Cells expressing the rod photoreceptor marker XAP2 (rPR; red); BrdU - immunoreactivity (yellow) identifies mitotically active cells in the periphery of the same flank reCells expressing the rod photoreceptor marker XAP2 (rPR; red); BrdU - immunoreactivity (yellow) identifies mitotically active cells in the periphery of the same flank recells in the periphery of the same flank retina.

We perform the transient silencing of several genes in parallel by RNA interference in order to identify those able to modify two types of DM1 biomarkers expressed by one DM1 - hES cell line progeny: the pathological intranuclear ribonucleoaggregates called foci and the insulin receptor splicing defect.

We have also identified a group of CD1c - restricted T cells that recognize a leukemia - associated lipid antigen and kill acute leukemia frequently expressing CD1c.

There are no specific markers to identify them; however, they are negative for hematopoietic cell markers like CD34 / 45 / HLA - DR and express CD90 / 73/105 on their surface 2, 3, 4.

To identify relevant P450s, the researchers created 27 different insect cell lines, each expressing a unique honeybee P450 gene.

The researchers particularly identified three novel candidate genes; KIRREL3 and SLIT1, with documented roles in immune cell development, and SERPINA9 expressed exclusively at the site (germinal center) where a B - cell starts producing IgA.

«Cells expressing each of these characteristics were identified across all tumors, suggesting cells sensitive or resistant to chemotherapy are both presents in the same tumor,» confirmed SteCells expressing each of these characteristics were identified across all tumors, suggesting cells sensitive or resistant to chemotherapy are both presents in the same tumor,» confirmed Stecells sensitive or resistant to chemotherapy are both presents in the same tumor,» confirmed Stewart.

We have recently identified which cells are uniquely responsible for the metastasis formation in OSCC, and they exhibit the following characteristics: i) they are exclusive in their ability to generate metastases; ii) they express the fatty acid translocase CD36, and express a unique lipid metabolic signature; iii) they directly link metastasis predisposition to dietary fat content; iv) they increase their metastatic initiation potency when treated with palmitic acid; v) they are highly sensitive to CD36 inhibition, which almost completely abolishes their metastatic potential in preclinical models (Pascual et al., Nature 2016).

«A recent report published in Nature by Descours et al. prompted great interest, as it claimed to have identified CD32 as one such marker that is selectively expressed on the majority of persistently infected CD4 T cells.

Inventors at MUSC have identified a unique human CD4 + T cell population that expresses high levels of surface CD26, termed CD26high T cells, which mediate durable antitumor immunity in vivo, and have immediate clinical relevance for designing new vaccines and cellular therapies.

We identify a population of mesodermal cells in a developing invertebrate, the marine annelid Platynereis dumerilii, that converges and extends toward the midline and expresses a notochord - specific combination of genes.

Following electroporation into R26 BirA cells, a cell line that expresses bacterial BirA ligase from the ROSA26 locus, hygromycin resistant clones (200 µg / ml) were expanded for Southern analysis to identify correct targeting events.

We hypothesize that SSEA3 expression is either identifying another less differentiated and / or tissue specific stem cell like population that is retrieved with the donor skin biopsy or that with culture, a subpopulation of fibroblasts may acquire the ability to express SSEA3.

The publication of the P. falciparum genome project in 2002 [10] identified the full complement of parasite proteins but progress in understanding the function of these proteins, including those displayed on the merozoite cell surface, has been hindered by the technical difficulties in expressing Plasmodium proteins in a functionally active form [11].

Recently, a large - scale microarray study characterized gene expression differences between current, former, and never smokers [5], and identified specific genes related to xenobiotic functions, anti-oxidation, cell adhesion and electron transport to be more highly expressed in current smokers relative to never smokers.