Sentences with phrase «identify gene pathways»
The project came out of a collaboration with Cold Spring Harbor Laboratory to identify gene pathways that could be used to breed crops with higher yields.
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The study was the first of its kind to employ genome - wide reverse engineering to identify the gene pathways that contribute to periodontitis.
Not exact matches
In many animal model systems, for example, the precise genes involved in sexual partner selection have been identified, and their neuro - biochemical pathways have been worked out in great detail.
«Transcriptomics identifies genes, signaling pathways that may regulate neurodegeneration.»
We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»
«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.
The team designed the Haploinsufficient / Triplosensitive Gene (HAPTRIG) computational tool to identify pathways significantly disrupted by the loss and gain of genes.
By studying these relationships, the researchers have discovered a new pathway to identify how genes influence disease, according to Boerwinkle.
«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»
«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.
Many of the genes identified by Dr. Papapanou and his team are implicated in immune and inflammatory pathways, confirming laboratory and clinical observations of the development of periodontal disease.
They identified previously unknown recurrent loss - of - function mutations that target genes regulating epigenetic pathways — ones that act on how tightly or loosely chromosomes are wound and thus accessible for genes to be expressed.
«This is an exciting study of a very rare bone disorder that not only identified the responsible mutation in half of the patients, but uncovered fundamental information about the role of a cancer - related gene in the metabolic pathways of normal bone,» said study co-senior author Joan Marini, Ph.D., M.D., of NICHD.
The team also identified genes that had not been previously linked to ASD, but are heavily involved in numerous protein interactions and signaling pathways.
We examined the biological pathways, or common links between genes, that might be affected in these 131 regions that were identified.»
By identifying novel genes and molecular pathways involved in shaping a taste cell's function, these findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine - tune a person's taste perception to encourage healthier eating.
The research further identified genes that seem to be acting together in groups or pathways.
After having identified the gene cluster for tilivalline synthesis, the scientists performed comprehensive biomolecular and molecular genetic experiments to track down the complete biosynthetic pathway of tilivalline.
To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.
It now appears that the clocks and clock - related genes — some 20 such genes have been identified — affect virtually all of the cells» metabolic pathways, from blood sugar regulation to cholesterol production.
The researchers also examined gene expression in pre-existing skin biopsies from the same twins to identify possible gene pathways linked to acne.
The latest findings open the prospect to identifying the whole pathway of genes involved in both homosexual and heterosexual orientation, says Dean Hamer at the US National Institutes of Health, who led the study that pinpointed chromosome X back in 1993.
He identified some genes in the pathway and studied how it was regulated, comparing it to bacteria and yeast.
After five years of research, they identified the gene regulation pathway, which involves the body's sodium sensor called Nax (scn7a) that triggers inflammation.
«We have already observed that gene egr - 4 is regulated by the epidermal growth factor receptor (EGFR) signaling pathway, so it will enable to identify also the factors that activate this pathway during anterior regeneration.
«By studying the epigenome, we also identified new pathways and molecular dependencies not apparent in previous gene expression and mutational studies,» Northcott said.
The researchers also determined that many of the 18 newly identified autism genes affect the operation of a small subset of biological pathways in the brain.
The Yale - led study performed whole exome sequencing ¬ — a technique for sequencing all the expressed genes in a genome ¬ — on TNBC tumors to identify mutations in specific genes or pathways that may indicate response or resistance to the standard of care, which is anthracycline / taxane (ACT) chemotherapy.
«Once you find metabolites and want to analyze them for new antibiotics or new pathways, you need the genome information to identify the enzymes and clone the genes.»
A companion paper published in BMC Evolutionary Biology by colleagues at the EPA lab in Narragansett, RI, that used a «candidate gene scan» approach — examining SNPs from 42 genes associated with the AHR pathway — also identified AHR2 as a gene that appears to be under selection and is likely to be involved in the resistance.
Clariom S Pico assays enable scientists to identify important expression changes in genes and pathways.
Pandolfi and colleagues sought to identify an additional tumor suppressing gene or pathway that may work in concert with PTEN to drive metastasis.
As described in the journal Genes & Development, the researchers identified a new pathway controlling heterochromatin organisation in mouse embryonic stem cells.
The results of this analysis identified a novel pathway and genetic mediator of metastasis for adenocarcinoma of the prostate, the androgen receptor gene.
Through the systematic analysis of ommochrome and porphyrin biosynthetic pathways, the authors identified several genes required for producing planarian pigment.
In a collaborative study, researchers from Chinese Academy of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations of tumor - associated genes and tumorigenic pathways in esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwide.
Use of exon - based transcriptome profiling to identify novel signaling pathways and survival - associated genes in diffuse large B - cell lymphoma.
Several of the identified genes were representative of pathways previously described in other tissues exposed to hypoxia, including genes in the stress response, apoptotic, proliferation, and synaptic transmission pathways.
Using genes from these chromosomal regions, Richter identified three new enzymes that function in terpene synthesis pathways to produce linalool, nerolidol, and other terpenes.
Our primary aim is to identify subgroups of rNB patients who have potentially targetable genetic (ALK, MAPK pathway, Metabolic - related genes) and / or immunologic (tumor - associated macrophage infiltration and / or programmed death ligand [PD - L1] expression) biomarkers in rNB.
«The bioinformatics tools have matured to the point that we can now find the proverbial «needle in a haystack,» meaning we can now identify genes and pathways that are unique to pathogenic microbes, which will focus future research efforts on these key pathogen - specific features,» Fouts said.
In recent decades, scientists have identified genes, enzymes, metabolic pathways and signaling molecules that control those activities.
Our BN analysis methods can be used to identify novel gene interactions and networks for advanced study of different biological networks and pathways.
However, many genes and pathways not yet described in the context of hypoxia were also identified.
The aim of this study is to identify potential key genes and pathways that are related to the calcification apparatus.
Identifying genes and regulatory pathways associated with the scleractinian coral calcification process
The Wnt and TGF - β signaling pathways were identified in the gene expression analysis as being up - regulated during the day (Fig. 4).
The genes identified by this study may implicate pathways involved in inflammation, movement of proteins within cells, and lipid transport as being important in the disease process.
«What is more, the technique identifies key genes and enriched gene ontology pathways, as well as categories related to stem cell differentiation — and specifically toward osteochondral lineages (that is, related to bone and cartilage tissue growth).»
Identification of genes that contribute to Alzheimer's disease risk and that influence other characteristics of Alzheimer's disease will reveal basic pathogenic mechanisms, identify proteins and pathways for drug development, and provide genetic methods for determining people at greatest risk for when preventative measures become available.