Sentences with phrase «identify genes associated with disease»

Conversely, fundamental research using mouse models can identify genes associated with disease and provide insights into pathogenic mechanisms underlying environment - driven diseases, including infectious diseases and cancer.

This breakthrough discovery was one of the first successful attempts to identify a gene associated with a disease.

Purpose: Many current studies are aimed at trying to identify genes associated with diseases in dogs, but we are looking to see if there might exist «protective genes» that could help protect against these same life - limiting diseases in the dog.

Not exact matches

The study identified yet another mutation — albeit a rare one — in the SCARB1 gene, also associated with elevated HDL levels, that raised coronary heart disease risk by a whopping 80 percent.

However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

Scientists have identified unique genetic signatures strongly associated with a long and healthy life, findings that could help to further the understanding of how certain genes may offer protection from common age - related diseases like cancer, dementia and cardiovascular disease.

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

With her expertise in handling large genetic datasets, Dr Knight helped identify the two gene variants associated with improved responses to rasagiline in early Parkinson disease (With her expertise in handling large genetic datasets, Dr Knight helped identify the two gene variants associated with improved responses to rasagiline in early Parkinson disease (with improved responses to rasagiline in early Parkinson disease (PD).

Researchers studying two generations of a family affected by pediatric acute lymphoblastic leukemia (ALL) have identified an inherited variation in the ETV6 gene that is associated with an increased risk of developing the disease.

This past September, a pair of research teams announced that they had identified three new genes associated with Alzheimer's disease.

A decade ago, they also identified a relationship between ALS and excess iron accumulation when they found that 30 percent of ALS patients in their clinic carried a variant of a gene known as HFE that is associated with iron overload disease.

«The ability to identify, characterize and validate gene targets that strongly associate or correlate with disease development or metastasis will facilitate early detection and appropriate treatments to tackle the disease at an early stage or before metastasis occurs.»

Previous studies have identified a number of risk genes responsible for making proteins that are associated with the disease.

They then scanned the scientific literature to identify human diseases associated with those genes and found 47 diseases.

In this study, we used ribosomal RNA gene sequencing to identify the zooxanthellae, bacteria and archaea associated with healthy and yellow band diseased (YBD) colonies in the Media Luna reef of La Parguera, Puerto Rico, in order to examine the influence of YBD on the Montastraea faveolata microbiome.

Work ranges from analysis of the functions of genes identified to cause eye diseases when mutated, to the direct effects of UV - light and other agents associated with the development of eye disease on mitochondrial and other cell functions.

Candidate gene and genome - wide association studies have identified variants associated with HBV - related disease progression or hepatocellular carcinoma in various populations [46][52].

The NIA recently awarded a 5 - year, $ 19.5 million grant to the Alzheimer's Disease Genetics Consortium (ADGC) to conduct a genome - wide association study (GWAS) to identify the remaining genes associated with an increased risk of developing late - onset Alzheimer's diseasDisease Genetics Consortium (ADGC) to conduct a genome - wide association study (GWAS) to identify the remaining genes associated with an increased risk of developing late - onset Alzheimer's diseasedisease (AD).

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

It would allow us to identify which genes associated with disease are active in our bodies and where, and analyze the regulatory mechanisms that govern the production of different cell types.

Isolated populations with enrichment of variants due to recent population bottlenecks provide a powerful resource for identifying disease - associated genetic variants and genes.

This research includes identifying additional genes associated with disease incidence in order to identify potential drug targets.

crd1 / rcd1b Test: A small deletion in PDE6B gene has been identified that is associated with the rcd1b disease in the American Staffordshire Terrier breed (2).