Sentences with phrase «identify haplotypes»

The short size of the locus was ideal for 454 sequencing, and because single - molecule reads are generated, the authors were able to identify haplotypes of somatic hypermutations carried by individual leukemic cells.

Genome - wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene «SP110 nuclear body protein'that was associated with increased risk of developing DM and early age of onset.

By identifying haplotypes from single - molecule reads, the authors were able to construct phylogenetic trees of the leukemic cells in a single patient, something that could only be done on the 454 platform.

Within this gene, the deCODE team identified haplotypes, or specific sets of genetic markers, that correspond both to significantly increased risk of stroke and to significantly decreased risk.

Not exact matches

Indeed, he notes, it's improbable that all of the previous genetic studies of red deer, including those living throughout Europe today, wouldn't have picked up any of the haplotypes he and his team identified in their new research.

The $ 138 million HapMap denotes haplotypes, stretches of DNA that are inherited together as unbroken blocks and can be identified by just a handful of DNA markers known as SNPS (single nucleotide polymorphisms).

This requires the development of powerful bioinformatic approaches that allow prediction of haplotypes from numerous variants, and the classification of haplotypes into functionally related categories, in order to identify those specific sequence variants, or combinations of variants, associated with the disease phenotype.

The research team, co-led by Dr Rollins and Professor Bill Sherwin of UNSW, in collaboration with the Department of Agriculture and Food in Western Australia, studied the DNA of 279 starlings near Munglinup in the south east of Western Australia and identified birds with a novel mitochondrial genome sequence (Haplotype H).

The process of figuring out which of these genetic differences lie on each chromosome is called haplotyping, and it's an important step toward identifying which version of a gene may cause disease.

Mendez et al. identify a Y chromosome haplotype that has not been characterized before and, with more work, they determine that it is nearly identical to a small group of Y chromosomes from Cameroon.

deCODE has identified both at - risk and pretective haplotypes within the PDE4D gene, and is applying its findings to develop novel drugs and diagnostics

Within these two regions we identified several partially overlapping haplotypes, predisposing somewhat differently to the two cancers.

The deCODE team, working with doctors and researchers at Iceland's National University Hospital and the Icelandic Heart Association, identified the PDE4D gene and significant haplotypes by analyzing detailed genotypic data from some 1800 participants in its stroke program, both patients and unaffected relatives, from across Iceland.

AMA1 is highly polymorphic — more than 300 unique AMA1 haplotypes have been identified worldwide and more than 200 at a single site in Mali [9].

Y - chromosome haplotypes were recovered by aligning reads against previously identified Y - chromosome contigs (12, 75), first against the contigs alone and then remapped against the full nuclear genome, including the Y - chromosome contigs, to control for repetitive regions.

We have identified a Y - chromosomal lineage that is unusually frequent in northeastern China and Mongolia, in which a haplotype cluster defined by 15 Y short tandem repeats was carried by approximately 3.3 % of the males sampled from East Asia.

September 23, 2003 deCODE has identified both at - risk and pretective haplotypes within the PDE4D gene, and is applying its findings to develop novel drugs and diagnostics deCODE's landmark study in the genetics of stroke, identifying the first gene ever linked to...

We developed a new approach to sequence generation for targeted base updates and used data from new genome mapping technologies and single haplotype resources to identify and resolve larger assembly issues.

199/3: 15 Imputation of rare variants from the new Haplotype Reference Consortium identifies associations missed by 1000 Genomes.

The genes were identified through population - and genome - wide linkage scans and association analyses of at - risk haplotypes utilizing genetic and clinical data from the 17,000 participants in deCODE's obesity program in Iceland.

We did however identify two regions where distinct haplotypes have swept in different populations, leading to increased population differentiation.

When Dr. Foley approached me to see if I was interested in the program coordinator position, I was working as postgraduate researcher on a project to identify the origins of the domestic dog through Y chromosome haplotype analysis.

So, if your dog has a percentage of Gray Wolf in them, that means we actually can identify wolf haplotypes.

The diversity of DLA class I and II haplotypes was low, with only 11 identified DLA class I and nine class II haplotypes.

Breeds identified by the UC Davis Veterinary Genetics Laboratory that share maternal haplotypes with English bulldogs

Four paternal haplotypes, with one occurring in 93 % of dogs, were identified using six Y - short tandem repeat (STR) markers.

Haplotypes identified in affected dogs are shown.

A smaller 31 Kb region containing an overlapping homozygous haplotype that contains a single gene, THBS2, was identified within affected breeds (Figure 5).

MtDNA RFLP data from Santa Cruz, Santa Rosa, San Nicolas, and San Clemente identified the same number or one fewer haplotypes than whole mitogenomes.

A positive correlation was identified between island area and the number of haplotypes recovered and haplotype diversity (Pearson's r = 0.80 p - value = 0.03 and r = 0.77 p - value = 0.04, respectively).

We identified two pairs of closely related haplotypes on each of the two most remote islands in the archipelago (San Nicolas and San Clemente), which indicates in situ evolution of island fox genetic variation.

Previous analyses using mtDNA RFLP's identified more mtDNA haplotypes than detected by our whole mitogenome (WMG) sequencing analysis on San Miguel (2 RFLP: 1 WMG genotypes) and Santa Catalina (3 RFLP: 2 WMG genotypes), suggesting a possible loss of mtDNA diversity on these islands as a result of population bottlenecks over the past 25 years [15].