Sentences with phrase «identify key cell»

Using mouse genetics in combination with novel sequencing technologies our lab is able to identify key cell types or candidate factors important for specific remodeling and repair processes of the heart.

Understanding the role of the niche requires identifying the key cell types that regulate the numerous processes that take place within the niche.

«These R2 neurons have higher firing rates the more sleep - deprived the fruit flies were and firing of these neurons puts flies to sleep, suggesting that we've identified the key cells responsible for sleep drive,» says Wu.

Not exact matches

By overlaying that information onto a computer model of the whole human genome, they were able to identify key factors involved in cell regulation

Along with the study's co-first authors, Drs. Aayoung Hong and Gatien Moriceau, Lo hypothesized that if they could identify the key tumor cell processes triggered by withdrawal of MAPK inhibitors, then scientists can exploit these process with existing or investigational drugs to trigger the maximal levels of tumor cell death immediately following cessation of the initial therapy.

One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage.

These cells play a key role in autoimmune disease — in which the immune system mistakenly identifies the body's own tissues as foreign and attack them.

Her pioneering work mapping the regulatory network of dendritic cells (DCs) identified a lineage of DCs that is now considered a key target to improve antiviral and antitumor immunity.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

«Regulator of chromosome structure crucial to healthy brain function and nerve development: Cohesin protein identified as key to control of chromosome structure underlying nerve cell network formation.»

CNIO's Bioinformatics Unit has been key in comparing 900 cell lines derived from up to 35 tumor types in order to identify unique aspects of melanoma.

T cells are key actors in the body's defenses, identifying foreign or diseased cells and leading an assault on them.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

«Scientists identify proteins crucial to loss of hearing: Proteins play key role in genes that help auditory hair cells grow.»

Further, Shankman identified a key gene, Klf4, that appears to regulate these transitions of smooth muscle cells.

What's more, they identified Cas as a critical, tissue - specific target of Hh signaling, which not only plays a key role in maintaining follicle stem cells but also assists in the diversification of their progeny.

«Protein key to cancer cells ability to spread identified.»

«Molecule identified that helps give resident T cells in the skin their anti-cancer punch: The molecule CD103 is key to the long - term residence of T cells in the skin and to their potent anti-tumor response against melanoma.»

For the first time, scientists at Newcastle University, UK, have identified that the activity of a key metabolic enzyme found in the batteries of human skin cells declines with age.

They also identified a key signaling molecule, an enzyme called Rho that stimulates stem cells to turn bone - like.

«In mammals, in the absence of haploid cells, other approaches have been used to identify key genes, such as interfering RNA, but they are sub-optimal methods.

Dr. Espen Spangenburg, associate professor of kinesiology, and his laboratory team are the first to identify that the BRCA1 protein is expressed in the skeletal muscle of both mice and humans, and that it plays a key role in fat storage, insulin response and mitochondrial function in skeletal muscle cells.

A team of investigators led by Rohit Kohli, MBBS, MS, of Children's Hospital Los Angeles, has identified key inflammatory cells involved in nonalcoholic fatty liver disease.

Kanneganti emphasized that their discoveries have fundamental importance, because they identify a key innate immune sensor that recognizes the influenza virus and a regulator of multiple cell death pathways.

A new report online May 15 in the Cell Press journal Trends in Genetics identifies a number of key challenges to consider as experts develop such programs.

In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune response.

«If we had just the (compromised) neural cells available, we wouldn't have been able to identify this key characteristic of AHDS.»

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

Research carried out by the University of Sussex and the Polish Academy of Sciences has identified two key proteins that allow mycobacterium tuberculosis, the causative agent of tuberculosis (TB), to «lay low» within cells designed to destroy them.

As a basis for their experiments, the researchers drew on mouse studies that have identified key regulatory mechanisms acting within and between different cell types to coordinate developmental programs.

In the latest study, published in Nature Microbiology, the team have identified two key proteins that malaria parasites need to escape red blood cells and infect fresh cells.

In a study recently published in the journal Scientific Reports, researchers in USF's Center of Excellence for Aging and Brain Repair say the results of their experiment are an early step in pursuing stem cells for potential repair of the blood - spinal cord barrier, which has been identified as key in the development of ALS.

«Scientists identify key defect in brain tumor cells.»

«Researchers identify key factor for reprogramming adult cells into stem cells.»

«Natural killer cells help to drive inflammation, insulin resistance: Study in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»

Researchers from RIKEN in Japan have identified a duo of histone proteins that dramatically enhance the generation of induced pluripotent stem cells (iPS cells) and may be the key to generating induced totipotent stem cells.

EDMONTON, ALBERTA — Researchers have identified a key cellular pathway by which the herbal medicine ginkgo biloba may protect brain cells.

A key challenge of treating these cancers has been to identify a way of eliminating the abnormal T - cells whilst sparing the healthy ones that play an essential role in providing protection against infections.

Richard H. Scheller (Genentech) and Thomas C. Südhof (Stanford University School of Medicine) identified and isolated many of this reaction's key elements, unraveled central aspects of its fundamental mechanism, and deciphered how cells govern it with extreme precision.

The study, «Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation,» was supported by the National Institutes of Health.

Here we identify protein kinase N1 (PKN1) as a novel key player in fine - tuning the balance between axonal outgrowth and presynaptic differentiation in the parallel fiber — forming (PF - forming) cerebellar granule cells (Cgcs).

An international research team led by Université de Montréal medical professor Christopher Rudd, director of research in immunology and cell therapy at Maisonneuve - Rosemont Hospital Research Centre, has identified a key new mechanism that regulates the ability of T - cells of the immune system to react against foreign antigens and cancer.

N. Yasui et al., «Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation,» Molecular Cell, doi: 10.1016 / j.molcel.2014.05.002, 2cell differentiation,» Molecular Cell, doi: 10.1016 / j.molcel.2014.05.002, 2Cell, doi: 10.1016 / j.molcel.2014.05.002, 2014.

We identified Protein Kinase C - theta as the first key protein that serves as master switch for determining the physiological outcome to initial T cell activation.

Medical professor Christopher Rudd and his research team have identified a key new mechanism that regulates the ability of T - cells of the immune system to react against foreign antigens and cancer.

Scientists at the Carnegie Institution have identified a gene, named scrawny, that appears to be a key factor in keeping a variety of stem cells in their undifferentiated state.

An international team of researchers including University of Melbourne staff has identified the exact biochemical key that awakes the body's immune cells and sends them into fight against bacteria and fungi.

Postdoctoral fellow Aaron Gitler now is searching for the original defect that the Parkinson's protein triggers in yeast cells in hopes of identifying the underlying disease pathway and key drug targets.

Key findings of this research, which was conducted by Shawn L. Chavez, PhD and her colleagues at Stanford University and analyzed at OHSU, showed that by looking at the duration of the first mitotic phase — a short period in the cell cycle — one can identify chromosomally normal versus abnormal embryos up to approximately the 8 - cell stage.

Klemke's laboratory has already identified several candidate proteins using this technique that may be key players in pseudopod formation and cell movement.