Sentences with phrase «identify key mechanisms»

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

Researchers in the laboratory of Whitehead Member Susan Lindquist have identified a key mechanism that enables pathogenic fungi to evolve drug - resistant capabilities with such distressing rapidity.

This study identified a key mechanism in chemotherapy resistance in hemangiosarcoma tumors.

Not exact matches

In addition to identifying key stressors and larger sociopolitical mechanisms related to homebirth transfers, they also consider possible solutions in the movement towards developing an integrated maternity system.

Published a month apart in PLOS Pathogens, the studies from Professor Ethan Bier's laboratory used a series of experiments to identify key pathways and mechanisms previously unknown or overlooked in the body's defenses.

Neuroscientists have already made great strides, identifying key brain regions and potential molecular mechanisms.

Now, by identifying the key molecular mechanism that enables a plant to minimize water loss, researchers may be one step closer to that goal.

New research from a team led by Wolf Frommer, director of the Plant Biology Department, Carnegie Institution for Science in Stanford, in collaboration with the Carter lab in Minnesota and the Baldwin lab at the Max Planck Institute for Chemical Ecology in Jena, Germany, now identified key components of the sugar synthesis and secretion mechanisms.

Scientists from The University of Manchester working with IBM Research have identified a key biological mechanism that for the first time explains why women with dense breast tissue are at greater risk of developing breast cancer.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

As a basis for their experiments, the researchers drew on mouse studies that have identified key regulatory mechanisms acting within and between different cell types to coordinate developmental programs.

«Natural killer cells help to drive inflammation, insulin resistance: Study in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»

ARL created a generalized model using an energetic formulation approach, which was key in identifying two important mechanisms for enabling high bending motion in soft biological actuators: (i) tuning physical properties (mechanical and geometric) via exploiting the interplay between the materials and dynamic nonlinearities to augment the motion; and (ii) highlighting the electromechanical coupling between the electrical field and nonlinear structural stiffness through the distributive actuation circuitries.

Richard H. Scheller (Genentech) and Thomas C. Südhof (Stanford University School of Medicine) identified and isolated many of this reaction's key elements, unraveled central aspects of its fundamental mechanism, and deciphered how cells govern it with extreme precision.

An international research team led by Université de Montréal medical professor Christopher Rudd, director of research in immunology and cell therapy at Maisonneuve - Rosemont Hospital Research Centre, has identified a key new mechanism that regulates the ability of T - cells of the immune system to react against foreign antigens and cancer.

Medical professor Christopher Rudd and his research team have identified a key new mechanism that regulates the ability of T - cells of the immune system to react against foreign antigens and cancer.

We were also the first to identify a new molecular mechanism driving pediatric GBM, namely recurrent somatic driver mutations in histone molecules that lead to amino - acid substitutions at key residues (K27M, K36M, G34V / R).

In 2007, he joined Columbia University as a post-doc, where he developed network - based computational approaches aimed at identifying key drivers of initiation and progression of cancer, as well as mechanisms of therapeutic response and drug resistance.

With collaborators in the biology department, Dr. Weiss applied these ultrasensitive techniques to investigate the Hedgehog signaling pathway — a critical mechanism that helps give rise to the spatial patterning in developing embryos, but has also been identified as a key culprit in up to 25 % of cancer deaths.

We have identified several of the key genes and molecular genetic mechanisms that have contributed to such diversity.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

We have identified a number of key transcription factors that are deregulated during this process, and we are using this information to investigate mechanisms by which differentiation can be reprogrammed in tumour cells.

«How cannabis causes paranoia: Using the intravenous administration of ∆ 9 - tetrahydrocannabinol (THC) to identify key cognitive mechanisms leading to paranoia» by Freeman et al. published in Schizophrenia Bulletin on Wednesday 16th July.

Known key pathological mechanisms are related to defects in structural proteins, nuclear proteins, intermediate filaments and other cyoskeletal proteins, mitochondrial energy production and ion channels, but new concepts and new genes are rapidly being identified.

The application of subclonal reconstruction methods is providing key insights into tumor evolution, identifying subclonal driver mutations, patterns of parallel evolution and differences in mutational signatures between cellular populations, and characterizing the mechanisms of therapy resistance, spread, and metastasis.

Key genetic mechanisms which help control blood pressure have been identified in a study.

The exception is this new research, published March 22 in Cell, which identifies the key cellular mechanisms behind vascular aging and the key role it plays on muscle health.

Gewertz identifies the key components of the program as being how they are funded, whether states are clear with districts about student eligibility to participate, and whether mechanisms are in place to ensure rigor.

The overall goal of this extension of our existing work in partnership with TFF and Achievement First Bridgeport Academy (AFBA) is to continue and expand our work in Bridgeport focusing in several keys areas: (1) building knowledge about (a) children's emerging skills and areas of challenge in the social - emotional domain and why these skills are critical to school success, and (b) the ways in which adult stress and skills in the social - emotional domain can impede or foster children's social - emotional skill development; (2) identifying, deploying, and evaluating strategies to build adult and child skills in social - emotional learning with an emphasis on the Tauck Family Foundation's (TFF) five essential SEL skills; and (3) developing and testing a performance management system for SEL that (a) guides the identification of strategies, (b) provides a mechanism for ongoing progress monitoring, feedback, and changes to practice, and (c) serves as an anchor point for ongoing coaching and support in using SEL strategies.

This program identifies key work zones that will require an enhanced TMP, with components such as work zone ITS, limited construction hours, night work, lane rental contracting mechanisms, and Traffic Incident Management (TIM) plans.

Identify the next steps in synthesis activities, methodologies, mechanisms, and approaches to address the identified key science questions.

Synthesize results from theoretical, idealized models, and complex GCM investigations into a common conceptual framework regarding key AMOC variability mechanisms and identify the resulting predictability of the AMOC.

KEY ACCOMPLISHMENTS • Restructured the supplies replenishing mechanism that resulted in 24 hour timely availability of all cleaning supplies and chemicals • Timely identified and fixed an electrical socket problem, saving the premises electrical appliances from further damage caused by low voltage • Earned the «Most Punctual Employee» award in 2014

Results: Three overarching themes were identified from Stage One, including: (1) «Experiences of learned helplessness» (e.g. the association between child conduct problems and family conflict and social isolation); (2) «Perceived benefits and mechanisms of change» (e.g. the links between positive outcomes and a number of factors, including key parenting skills, social support, longer - term resilience and commitment, and facilitative organisational practices); and (3) «Challenges in programme implementation» (e.g. cultural discomfort with praise and positive attention, conflict with partners; and organisational difficulties with fidelity, attrition and sustainability).