Sentences with phrase «identify key molecules»

«The goal of our research is to identify key molecules that govern metastasis and use them as targets for the development of new drugs.»

«A molecular atlas of calcific aortic valve disease: Study builds molecular networks of calcific aortic valve disease to identify key molecules and therapeutic targets for a disease that affects one in four older Americans.»

«Researchers identify a key molecule in psoriasis development.»

Jules Hoffmann of the University of Strasbourg in France first identified a key molecule, called Toll, involved in the innate immune response in fruit flies.

Not exact matches

For the first time, the response of more than 10,000 genes was followed simultaneously, which identified brassinosteroids and auxins and their signalling molecules as key to the growth stimulation observed in biochar.

Yet in a study led by Aimy Sebastian, a graduate student in the School of Natural Sciences at UC Merced who is conducting her Ph.D thesis work under Loots, identified the secreted bone protein Sclerostin (SOST), as a key molecule dysregulated as a result of prostate cancer - bone microenvironment interactions.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

While the bulk of CureVac's prize money will go to basic molecular immunology research, Hoerr says he also wants to set aside a portion to pay tribute to Miescher, the biologist from Switzerland who identified nucleic acids, a family of key biological molecules that includes DNA and RNA, in his lab in Tübingen.

An international research team identifies for the first time a key enzyme for the synthesis of glycoconjugates (sugars linked to other molecules) in Plasmodium falciparum and other intracellular parasites belonging to the large phylum Apicomplexa.

«Molecule identified that helps give resident T cells in the skin their anti-cancer punch: The molecule CD103 is key to the long - term residence of T cells in the skin and to their potent anti-tumor response against melanomaMolecule identified that helps give resident T cells in the skin their anti-cancer punch: The molecule CD103 is key to the long - term residence of T cells in the skin and to their potent anti-tumor response against melanomamolecule CD103 is key to the long - term residence of T cells in the skin and to their potent anti-tumor response against melanoma.»

They also identified a key signaling molecule, an enzyme called Rho that stimulates stem cells to turn bone - like.

Her group is actively working to identify new molecules key to the disease process that could become potential drug targets.

A key problem with the current system is that companies tend to work in parallel, identifying similar or identical targets and developing their own molecules — unaware of other similar products that have already been tested and discarded.

We were also the first to identify a new molecular mechanism driving pediatric GBM, namely recurrent somatic driver mutations in histone molecules that lead to amino - acid substitutions at key residues (K27M, K36M, G34V / R).

Specific Aim 2: Having utilized mutant mice to identify the key players in AMD pathology from Specific Aim 1, we will develop and test molecules that target either the anaphylatoxins or the MAC, or both, in the context of practical therapies that can be utilized in humans.

A team of researchers based partly in South Africa has identified a key set of immune system molecules that helps determine how effectively a person resists infection with human immunodeficiency...

We have identified the coral homologs of many of the key molecules that are involved in apoptotic and cell death pathways in higher organisms.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

This included generated panels of monoclonal antibodies to key surface molecules, some of which enabled CD4 + T cell subsets to be separated out into those that mediated pathology and identify those CD4 + T cells, regulatory T cells, that controlled them.

Later on, scientists identified a molecule, B7 - H1, subsequently renamed PD - L1, which binds to PD - 1, clicking like a key in a lock.