Sentences with phrase «identify key mutations»

By assessing the incidence of a particular mutation or the frequency at which certain genes / pathways are altered across multiple patients (of the same tumor type), it should be possible to identify key mutations.

If researchers can trace the bacterium's evolutionary history, they might be able to identify the key mutations that trigger virulence or adaptation to different habitats, for example.

Not exact matches

She says mutations in key players of the mTOR pathway, a molecular pathway present and active in several types of cancer, have been identified in pNETs.

So some researchers have started with clinical mutations that impair key traits, then traced the genes» evolution, an approach that has identified a handful of tantalizing genes.

Identifying the key players behind mutations and cancer may not immediately lead to therapies, he said, but it's important to understand the process.

They then identified the putative causal mutations in genes controlling shattering (a key domestication trait among cereal crops).

The color - coded list identifies documented mutations in key viral genes, along with literature citations and a description of how the mutation is believed to change biological function.

We were also the first to identify a new molecular mechanism driving pediatric GBM, namely recurrent somatic driver mutations in histone molecules that lead to amino - acid substitutions at key residues (K27M, K36M, G34V / R).

We identified homozygous inactivating mutations in RAB3GAP, encoding RAB3 GTPase activating protein, a key regulator of the Rab3 pathway implicated in exocytic release of neurotransmitters and hormones, in 12 families with Micro syndrome.

The application of subclonal reconstruction methods is providing key insights into tumor evolution, identifying subclonal driver mutations, patterns of parallel evolution and differences in mutational signatures between cellular populations, and characterizing the mechanisms of therapy resistance, spread, and metastasis.