Sentences with phrase «identify key pathways»

Published a month apart in PLOS Pathogens, the studies from Professor Ethan Bier's laboratory used a series of experiments to identify key pathways and mechanisms previously unknown or overlooked in the body's defenses.

«This is a seminal step in identifying key pathways and molecules involved in kidney cancer so that specific therapies that target these new genes can be developed to treat this cancer.»

By identifying the key pathways affected by age in mice we have a better idea of what to look for in humans.»

Not exact matches

The introduction of the GCSE is also identified as a key educational reform, opening pathways for the majority.

Key brain regions have been identified by imaging studies, as have key neurochemical pathways bringing about the possibility of using drugs to block the nocebo effeKey brain regions have been identified by imaging studies, as have key neurochemical pathways bringing about the possibility of using drugs to block the nocebo effekey neurochemical pathways bringing about the possibility of using drugs to block the nocebo effect.

Two new members of a key pathway responsible for pattern formation during vertebrate development have been identified.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

«We identified the cytosolic protein Vms1 as a key component of a novel pathway termed mitoRQC that protects mitochondria from the toxic effects of such aberrant proteins,» explain the authors of the study.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

She says mutations in key players of the mTOR pathway, a molecular pathway present and active in several types of cancer, have been identified in pNETs.

One of the most robust alterations was observed in the JAK - STAT3 pathway and the production of serum amyloid A (SAA)-- a protein which has only recently been identified as a key player in the body's immune response.

Kanneganti emphasized that their discoveries have fundamental importance, because they identify a key innate immune sensor that recognizes the influenza virus and a regulator of multiple cell death pathways.

When the researchers used optogenetics, a biological technique which involves the use of light to control neurons, to inhibit the key social - spatial pathway they had identified in the brain, the test mouse wandered freely through the space.

EDMONTON, ALBERTA — Researchers have identified a key cellular pathway by which the herbal medicine ginkgo biloba may protect brain cells.

Now a team has elucidated the biochemical pathway responsible, as well as identified the key enzymes involved.

«Nutrient sensor in key growth - regulating metabolic pathway identified.»

«The bioinformatics tools have matured to the point that we can now find the proverbial «needle in a haystack,» meaning we can now identify genes and pathways that are unique to pathogenic microbes, which will focus future research efforts on these key pathogen - specific features,» Fouts said.

With collaborators in the biology department, Dr. Weiss applied these ultrasensitive techniques to investigate the Hedgehog signaling pathway — a critical mechanism that helps give rise to the spatial patterning in developing embryos, but has also been identified as a key culprit in up to 25 % of cancer deaths.

A key next step in the ALS investigation will be to identify the pathways that lead to loss of the inhibitory neurons and the behavioral defects.

Postdoctoral fellow Aaron Gitler now is searching for the original defect that the Parkinson's protein triggers in yeast cells in hopes of identifying the underlying disease pathway and key drug targets.

The aim of this study is to identify potential key genes and pathways that are related to the calcification apparatus.

«What is more, the technique identifies key genes and enriched gene ontology pathways, as well as categories related to stem cell differentiation — and specifically toward osteochondral lineages (that is, related to bone and cartilage tissue growth).»

The Gladstone team had profiled changes in gene expression using DNA microarrays, which provides an unbiased method for identifying key biological pathways.

We identified homozygous inactivating mutations in RAB3GAP, encoding RAB3 GTPase activating protein, a key regulator of the Rab3 pathway implicated in exocytic release of neurotransmitters and hormones, in 12 families with Micro syndrome.

The key biological pathways that are identified will then be targeted therapeutically through rational clinical trial strategies.

We are currently identifying the downstream effectors of this CAMKK2 - AMPK kinase pathway including Tau and some key effectors of autophagy.

This is why recent work in the field of cancer research has focused on picking apart the complex cellular pathways involved in the development of different cancers and identifying the roles of key proteins involved, with the goal of being able to discriminately and effectively eliminate cancerous cells from the body.

Neuroinflammation and ferroptosis were identified as key molecular pathways underlying iron toxicity.

We have identified the coral homologs of many of the key molecules that are involved in apoptotic and cell death pathways in higher organisms.

Scientists in the lab of Whitehead Institute Member David Sabatini have for the first time identified a protein that appears to be a nutrient sensor for the key growth - regulating mTORC1 metabolic pathway.

Using a new in vivo screening system, Whitehead Institute researchers have identified a protein in a key metabolic pathway that is essential in estrogen receptor (ER)- negative breast cancer.

Identifying any Hymenoptera - specific immune pathways or effectors that may exist is also of key importance for understanding the biology of host - pathogen interactions that may be relevant for such challenges as colony collapse disorder [42]--[44].

To identify key molecular mediators of the ABL kinases implicated in the regulation of the ABL1 / ABL2 - dependent pathways, we analyzed the expression of individual genes for transcripts altered by loss of the ABL kinases.

University of California San Diego (UCSD) School of Medicine researchers have identified an enzyme that plays a key role in controlling these metabolic changes, suggesting we could tweak this pathway artificially to help our bodies burn fat more efficiently.

By assessing the incidence of a particular mutation or the frequency at which certain genes / pathways are altered across multiple patients (of the same tumor type), it should be possible to identify key mutations.

By comparing key biochemical reactions in the cells of fasted and fed scid and B6 mice, the research team was able to identify and describe the highlighted steps (formerly missing links) in the following feeding - induced insulin signaling pathway.

The Diplomás team has identified four key policy areas to target as they work towards the attainment goal: counseling and advising, dual credit, student support pathways, and college affordability.13 P16Plus supports these policy areas using data to help inform those efforts that are most successful for students.

Many residents identify this strong financial support as a key reason why they chose SFTR over other pathways into teaching.

Through the development of the Organizer, we have identified key considerations for policymakers, practitioners, and the public as they reflect on the Pathways and Supports strand within their local contexts.

Key sectors of the economy identified for building career pathways include STEM fields such as information technology, health care, and advanced manufacturing.

• Provide a clear, evidence - based explanation of the role played by different parts of the energy sector in causing air pollution • Present detailed projections of the energy sector and related air quality pathways in different countries and sectors, based on known energy, climate and air quality policies, and the key implications for policymakers • Identify additional policy measures that can materially improve the outlook for energy - related air pollution, examining both the co-benefits and trade - offs with other energy and climate objectives • Based on analysis of different policy options, distil the key findings of the report into a clear set of implications and recommendations for policymakers

The U.S. Department of Health and Human Services identified career pathways as a key strategy to help states and programs address inconsistent compensation, expectations, and professional development across sectors.54 Career pathways identify a sequence of credentials that are reflective of progressively higher competencies and are tied to particular roles or job titles.

Strategies: Increase number of Aboriginal teachers; develop pathways in education, training and employment; identify key strategies and negotiate with DEST and other stakeholders.

assisting agencies to address key barriers to the employment of Aboriginal and Torres Strait Islander employees, by identifying pathways to employment that allow Indigenous people to develop the required skills and capacity to work within the APS;