Sentences with phrase «identify mechanisms of resistance»
The lab of Elisa Oricchio at EPFL has now carried out a study to identify mechanisms of resistance to ibrutinib.
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Identifying resistance mechanisms and creating non-invasive tests to aid in the selection and monitoring of patients during clinical trials.
A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.
Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cancer.
«Dr. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease - causing organism, such that resistance is minimized or eliminated.»
Published in Nanomedicine, the study identified a new mechanism of targeting multi-subunit complexes that are critical to the function of viruses, bacteria or cancer, thus reducing or possibly even eliminating their resistance to targeted drugs.
Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»
The second report, identifies the immunotherapy resistance mechanism in melanoma cells, is from a group led by Kai Wucherpfennig, MD, PhD, director of Dana - Farber's Center for Cancer Immunotherapy Research, and Shirley Liu, PhD, of Dana - Farber.
At this stage, there are several hypotheses as to the nature of the mechanism, but it is very likely that Busseola fusca has developed an unconventional resistance mechanism yet to be identified.
- lactamase inhibitors, the targets identified by the researchers at the University of Copenhagen and Ross are not directly implicated in the mechanism of antibiotic resistance.
«Natural killer cells help to drive inflammation, insulin resistance: Study in mouse models of diabetes identifies key immune mechanisms in abdominal fat.»
Thus, in discovering that NK cells control ATMS and consequently inflammation, the Joslin scientists have identified a new mechanism in the development of obesity - induced insulin resistance in mouse models.
In 2007, he joined Columbia University as a post-doc, where he developed network - based computational approaches aimed at identifying key drivers of initiation and progression of cancer, as well as mechanisms of therapeutic response and drug resistance.
use CRISPR - Cas technology to carry out genome - wide screens of gene - gene, gene - drug and cancer - microenvironment interactions in cells and mice in order to explore fundamental biology and to identify drug targets and drug resistance / sensitisation mechanisms.
Among other things, we have identified one mechanism of multi-drug resistance (MDR) involving P - glycoprotein (Pgp) which functions as a drug efflux pump of broad specificity.
«Whilst we have not yet identified the precise mechanism of action or resistance to artemisinin, this research represents substantial progress in that direction.
This target identification platform is used to identify novel targets and rational combinations and mechanisms of resistance to our current programs.
My studies of cancer genomes have led to characterization of multiple pediatric and adult tumor types, to development of methods that identify and characterize changes in genomic heterogeneity, to defining acquired resistance mechanisms to targeted therapies and to designing novel, personalized vaccines for individual patients.
Here, we report the first mechanistic description of talazoparib resistance, the first BRCA2 reversion mutations identified in prostate cancer, and the first cases of multiclonal BRCA2 reversion mutations as a mechanism of PARPi resistance.
His research aims to understand mechanisms of resistance to targeted therapies in cancer and identify potential therapies to overcome that resistance.
The application of subclonal reconstruction methods is providing key insights into tumor evolution, identifying subclonal driver mutations, patterns of parallel evolution and differences in mutational signatures between cellular populations, and characterizing the mechanisms of therapy resistance, spread, and metastasis.
RESULTS: Researchers identify a chemotherapy resistance mechanism in hemangiosarcoma tumor cells Hemangiosarcoma is a common and deadly tumor of dogs.