Sentences with phrase «identify novel therapeutic targets in»
Because of the ease with which the CRISPR / Cas9 system can be applied, it has quickly become a robust tool for generating accurate genetic disease models in the laboratory and for identifying novel therapeutic targets in the clinic.
http://www.closerlookatstemcells.org/ Not exact matches
Further exploration of the TCA cycle, using metabolomics, may identify novel therapeutic targets for CKD and in turn may help us evaluate the effects of promising interventions.»
The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.
We are looking at the role of complement proteins in inflammatory diseases such as atherosclerosis, to identify novel therapeutic targets.
Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma
Mapping the epigenome will allow Vijay and his team to zoom in on those genes with the greatest likelihood to contribute to disease, and the cell types in which they act, and therefore will help identify novel therapeutic targets.
His research focuses on studying the role that SUMOylation (a protein modification pathway) plays in Huntington's disease, with hopes of targeting the SUMO pathway to identify novel therapeutic targets.
The results of our studies should identify potential mechanisms underlying the white matter abnormalities seen in many degenerative diseases, and may reveal novel therapeutic targets for regenerative medicine.
«We believe the use of this index in future studies may help identify novel therapeutic targets against cancer,» Dr. Noushmehr said.
Our goal is to identify novel therapeutic targets and participate in both preclinical and clinical studies of new drugs and other interventions.
This study identified 1,317 distinct genes found to be knocked out in humans; many of these genes (e.g., APOC3, PLA2G7, LPA) are being pursued as therapeutic targets, whereas many others are novel genes of unknown function.
To translate advances in our understanding of molecular mechanisms of oncogenesis and tumor progression into novel therapeutic strategies.With primary focus on lung cancer, melanoma, and lymphoma / leukemia, we will use the strength of in - depth molecular and phenotypic characterization of tumor heterogeneity to identify new targets and translate those into new therapeutic opportunities.